Schizophrenia

Contributors
Preface
1 Research on Life-Span Development in Schizophrenia
Impediments to the Study of the Life Course of Schizophrenia
Methodological Approaches to Longitudinal Research on Schizophrenia
Summary
References
Part I Perinatal Factors and Infancy
2 Genetic and Perinatal Factors in the Etiology of Schizophrenia
Introduction
The Copenhagen High-Risk Study
A Research Framework: Gene-Environment Interaction
An Empirical Test
Conclusions
References
3 Neurobehavioral Development of Infants at Risk for Schizophrenia: A Review
Overview of Existing Studies
Neonatal Behavior
Postneonatal Behavior
Relation of Other Biological and Social Factors to Infant Behavior
Prediction from Infancy to Later Behavior
Summary
References
4 Early Social and Affective Development in Schizophrenic Offspring
Evidence for Social and Emotional Competence: Social Interaction
Evidence for Social and Emotional Competence: Clinical and Diagnostic Assessments
Quality of Parenting by Schizophrenics and Its Role in Children's Social and Affective Development
Conclusions
References
Part II Childhood and Adolescence
5 Childhood-Onset Schizophrenia: Developmental Perspectives on Schizophrenic Disorders
Clinical Presentation
Onset, Precursor States, and Early Symptom Development
Clinical Heterogeneity
Course
Treatment
The Search for Etiological Pathways
Conclusions
References
6 The Prediction of Psychiatric Disorders in Late Adolescence
The New York High-Risk Project
Longitudinal Analyses of Attention
Early Attentional Deviance and Adolescent Adjustment
Summary
References
7 Cognitive and Linguistic Functions of Adolescent Children at Risk for Schizophrenia
Study of Language and Cognition in the High-Risk Paradigm
Specific Content Areas Investigated in Adolescents
Consistency of Deviance across Measures
Early Attention Deficits as a Predictor of Later Maladjustment
Profile of Performance during the Adolescent Risk Period
Conclusions
References
8 Longitudinal Studies of Premorbid Development of Adult Schizophrenics
Dated Conceptions of the Longitudinal Course of Schizophrenic Disorders
Contemporary Studies of Developmental Precursors, Prognostic Signs, and Outcome
Conclusions
The Most Promising Leads for Further Research on Premorbid Development
References
Part III Adulthood: The Onset and Course of Clinical Symptoms
9 Ontogenetic Implications of Sex Differences in Schizophrenia
Premorbid Development
Onset and First Hospital Admission Age
Clinical Picture at Onset-First Admission
Response to Treatment
Ontogenetic Processes
Future Directions
References
10 Emotion and Attachment in Families of Schizophrenics: The Struggle for Recovery
Expressed Emotion
Family-Based Intervention Studies
Yale Psychiatric Institute Family Study
Concluding Remarks
References
11 Late-Onset Schizophrenia
Historical Perspectives
Epidemiology
Clinical Picture
Etiology of Late-Onset Schizophrenia
Differential Diagnosis
Course and Prognosis
Treatment
Conclusions
References
12 Aging and Schizophrenia: Plasticity, Reversibility, and/or Compensation
Introduction
Biological Aging
Long-Term Outcome of Schizophrenia
New Concepts in Adult Development
Late-Onset Schizophrenia
Discussion
References
Part IV Developmental Conceptualizations of Schizophrenia
13 The Development of Liability to Schizophrenia: Early and Late Developmental Models
Early versus Late Developmental Models of Schizophrenic Liability
Early Childhood Abnormalities among Preschizophrenic Subjects
Inferred Early Abnormalities among Preschizophrenic Patients
Early Environmental Insults among Preschizphrenic Patients
An Alternative Hypothesis: A Late Developmental Genetic Model
Conclusions
References
14 Developmental Trajectories in Schizophrenia: Elucidating the Divergent Pathways
Sources of Variability among Patients
Neurodevelopmental Models of Schizophrenia
An Archival-Observational Approach to Research on the Development of Schizophrenia
Conclusions
References
Index
List of Previous Volumes