Genetics and Cancer Susceptibility
Published on 12. April 1996
Book
Hardback
280 pages
978-0-471-13777-1 (ISBN)
Description
Recent advances in molecular genetics have provided new information facilitating identification of human subpopulations at increased risk for cancer development. This volume reviews the impact of both intrinsic genetic factors and extrinsic modifiers on human cancer risk. Emphasis is on susceptibility factors that are targets for chemical carcinogens, on intrinsic factors that modify cancer risk and on biomonitoring and extrinsic risk modification.
More details
Series
Language
English
Place of publication
New York
United States
Publishing group
John Wiley and Sons Ltd
Target group
College/higher education
Professional and scholarly
Illustrations
Illustrations
Dimensions
Height: 236 mm
Width: 157 mm
Weight
539 gr
ISBN-13
978-0-471-13777-1 (9780471137771)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
Genetic Basis of Human Cancer Susceptibility; Identification of BRCA1 - Implications for Risk Assessment; Tumor Suppressor Genes; A Model for Development of Human Breast Cancer - The Role of Human Activated pp60c-src in Mammary Carcinogenesis in Transgenic Mice; Effects of p53 Loss on Genetic Instability and Tumor Progression in a Mouse Mammary Cancer Model; Genetic Dissection of Tumor Susceptibility - The Mouse Model and Human Implications; Genetic Susceptibility to In Vivo and In Vitro Cell Transformation; A Novel Genetic Locus (TLS1) That Regulates N-Methy-N-Nitrosourca Induced Thymic Lymphoma Development in Mice; Genetic Control of Murine Hepatocarcinogenesis; Genetic Susceptibility to Tumor Progression; One Decade of Comparative Molecular Carcinogenesis; Validation Issues for the Use of Transgenic Mouse Mutation Assays in Risk Assessment; The Validation of Susceptibility Biomarkers in Epidemiologic Studies; Legal and Ethical Issues in Screening for Genetic Susceptibility; Metabolic Phenotypes and Carcinogen-DNA Adducts in Humans; Genetic Polymorphisms and Increased Cancer Risk; Endogenous DNA Damage and Its Repair; Epidemiology of Susceptibility to Breast Cancer; DNA Repair and the Epidemiology of Basal Cell Carcinoma; The Role of DNA Repair in Mutagenesis and Carcinogenesis; Human Health Risk Assessment Research Needs; Future Directions for Risk Assessment - From Host Factors to Genetic Susceptibility; Carcinogen-Derived Biomarkers and Tobacco Related Cancer; Aflotoxin and Hepatitis B Virus as Risk Factors for Hepatocellular Carinoma; Diet Inventervention for Modifying Cancer Risk.