Myocardial Preconditioning
Published on 20. November 2013
Book
Paperback/Softback
XIII, 285 pages
978-3-662-22208-9 (ISBN)
Description
This book is about the unique ability of the heart to protect itself against the serious consequences of an abrupt reduction in blood flow to the myocardium - a phenomenon which is switched on by stress and termed myocardial preconditioning. This volume describes the main features and characteristics of preconditioning, with respect to the time-course of the protective effect of the phenomenon (first and second windows) and the different sequelae of myocardial ischaemia against which it protects, such as myocardial injury, arrhythmias and contractile dysfunction. The proposed mechanisms underlying the fascinating form of cardioprotection are discussed. Among these are the role of endogenous labile mediators, receptor-linked G proteins, ATP-sensitive potassium channels and protein kinase C activation.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1996
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Research
Illustrations
XIII, 285 p.
Dimensions
Height: 25.4 cm
Width: 17.8 cm
Weight
581 gr
ISBN-13
978-3-662-22208-9 (9783662222089)
DOI
10.1007/978-3-662-22206-5
Schweitzer Classification
Other editions
Additional editions
Cherry L. Wainwright | James R. Parratt
Myocardial Preconditioning
Book
07/1996
Springer
€85.59
Article exhausted; check different version
Content
1. Preconditioning Against Myocardial Infarction-Its Features and Adenosine-Mediated Mechanism.- 2. Does Preconditioning Reduce Lethal Mechanical Reperfusion Injury?.- 3. Ischemic Preconditioning Markedly Reduces the Severity of Ischemia and Reperfusion-Induced Arrhythmias; Role of Endogenous Myocardial Protective Substances.- 4. The Protective Effects of Preconditioning on Postischemic Contractile Dysfunction.- 5. Reduction of Infarct Size-"Preconditioning at a Distance".- 6. Novel Approaches to Myocardial Preconditioning in Pigs.- 7. Preconditioning in the Human Heart: Fact or Fantasy?.- 8. Role of ATP-Sensitive Potassium Channels in Myocardial Preconditioning.- 9. The Role of G Proteins in Myocardial Preconditioning.- 10. Mimicking Preconditioning with Catecholamines.- 11. Activation of Protein Kinase C is Critical to the Protection of Preconditioning.- 13. The Mechanism of Preconditioning-What Have We Learned from the Different Animal Species?.- 13. Myocardial Stress Response, Cytoprotective Proteins and the Second Window of Protection Against Infarction.- 14. Delayed Ischemic Preconditioning Induced by Drugs and by Cardiac Pacing.- 15. Cardioprotective Effects of Chronic Hypoxia: Relation to Preconditioning.