Transgenic Animals as Model Systems for Human Diseases
Published on 29. April 1993
Book
Hardback
XII, 151 pages
978-3-540-56281-8 (ISBN)
Description
Some of the current concepts used in transgenic research, an increasingly important tool to study the regulation and function of genes, are illustrated in this book. With these techniques, animal models can be used to study human diseases; this opens up new possibilities in both applied and basic research. Specifically, the ability to introduce genes into the germline of mice and the successful expression of the inserted gene within an organism provide new insights and opportunities for biomedical research. The discussion here shows how a detailed analysis of the underlying molecular mechanisms will provide new insights into the genetic origin of certain diseases and will lead to a better understanding of normal and abnormal physiological processes.
More details
Series
Language
English
Place of publication
Heidelberg
Germany
Publishing group
Springer Berlin
Target group
College/higher education
Professional and scholarly
Illustrations
8
77 s/w Abbildungen, 8 s/w Tabellen
77 black & white illustrations, 8 black & white tables, biography
Dimensions
Height: 210 mm
Weight
325 gr
ISBN-13
978-3-540-56281-8 (9783540562818)
DOI
10.1007/978-3-662-02925-1
Schweitzer Classification
Other editions
Additional editions
Erwin F. Wagner | F. Theuring
Transgenic Animals as Model Systems for Human Diseases
E-Book
04/2013
Springer
€96.29
Available for download
Erwin F. Wagner | F. Theuring
Transgenic Animals as Model Systems for Human Diseases
Book
11/2012
Springer
€106.99
Shipment within 7-9 days
Content
1 The Human Renin-Angiotensin System in Transgenic Rats - New Tools for Antihypertensive Therapy.- 2 Probing the Genetics of Atherosclerosis in Transgenic Mice.- 3 The PrP-less Mouse: A Tool for Prion Research.- 4 The Carboxyterminal Fragment of the Alzheimer Amyloid Protein Precursor Causes Neurodegeneration In Vivo.- 5 Transgenic Models of Chronic Arthritis and of Systemic Tumour Necrosis Factor-Mediated Disease in Mice Expressing Human Tumour Necrosis Factor.- 6 Mammary Neoplasia in Mouse Mammary Tumor Virus-Transforming Growth Factor ? Transgenic Mice.- 7 Exploring the Pathogenic Potential of c-fos, Polyoma Middle T and Human Foamy Virus in Transgenic Mice.- 8 Transgenic Animals as Bioreactors for Therapeutic and Nutritional Proteins.- 9 Targeted Inactivation of the Muscle Regulatory Genes Myf-5 and MyoD: Effect on Muscle and Skeletal Development.