Post-Translational Modifications in Health and Disease
Published on 13. October 2010
Book
Hardback
XIV, 490 pages
978-1-4419-6381-9 (ISBN)
Description
Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
More details
Series
Edition
2011
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Research
Illustrations
XIV, 490 p.
Dimensions
Height: 241 mm
Width: 160 mm
Thickness: 32 mm
Weight
916 gr
ISBN-13
978-1-4419-6381-9 (9781441963819)
DOI
10.1007/978-1-4419-6382-6
Schweitzer Classification
Other editions
Additional editions
Cecilio J. Vidal
Post-Translational Modifications in Health and Disease
Book
12/2012
Springer
€213.99
Shipment within 15-20 days
Cecilio J. Vidal
Post-Translational Modifications in Health and Disease
E-Book
10/2010
1st Edition
Springer
€213.99
Available for download
Content
Isoprenoid Modifications.- GPI-Anchored Proteins in Health and Disease.- Protein Oxidation.- Involvement of S-Nitrosylation in Neurodegeneration.- Protein Glycosylation, and Congenital Disorders of Glycosylation.- Defective Glycosylation of Dystroglycan in Muscular Dystrophy and Cancer.- Protein kinase A: The Enzyme and Cyclic AMP Signaling.- The Protein Kinase C Family: Key Regulators Bridging Signaling Pathways in Skin and Tumor Epithelia.- Maintaining Energy Balance in Health and Disease: Role of AMP-activated Protein Kinase.- Protein Phosphatases in the Brain: Regulation, Function and Disease.- Covalent Protein Modification as a Mechanism for Dynamic Recruitment of Specific Interactors.- Regulation of Gene Expression by the Ubiquitin-Proteasome System and Implications for Neurological Disease.- Small Ubiquitin-like Modifiers and other Ubiquitin-like Proteins.- ER-associated Degradation and its Involvement in Human Disease: Insights from Yeast.- Regulation of Chromatin Structure and Transcription via Histone Modifications.- Chromatin: the Entry to and Exit from DNA Repair.- Poly(ADP-rybosyl)ation of Chromosomal Proteins: Epigenetic Regulation and Human Genomic Integrity in Health and Disease.- Post-translational Proteolytic Processing on Intracellular Proteins by Cathepsins and Cystatins.- Metalloproteases and Proteolytic Processing.