Separation Methods in Drug Synthesis and Purification: Volume 8
2nd Edition
Published on 18. June 2020
Book
Paperback/Softback
788 pages
978-0-444-64070-3 (ISBN)
Description
Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods.
More details
Series
Edition
2nd edition
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
Professional and scholarly
a wide range of professionals from all areas of the chemical and pharmaceutical industries: skilled practitioners in the field of separation science; professionals working in the pharmaceutical industry; academic researchers postgraduate level and above
Product notice
Paperback (trade)
Dimensions
Height: 229 mm
Width: 152 mm
Thickness: 40 mm
Weight
1039 gr
ISBN-13
978-0-444-64070-3 (9780444640703)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
06/2020
2nd Edition
Elsevier
€265.00
Available for download
Person
Dr. Klara Valko is an enthusiastic principal scientist and consultant supporting early drug discovery and lead optimization with over 22 years of experience. She has been an Honorary Professor at UCL School of Pharmacy since 2004, leading the Physchem/ADME module (London, UK) for Drug Discovery MSc. Her many contributions to the field include the development of biomimetic HPLC methods for high throughput measurements of serum albumin, glycoprotein and phospholipid binding, the invention of the Chromatographic Hydrophobicity Index for fast determination of compounds' lipophilicity using generic gradient reversed phase chromatography, and more.
Content
Preface
Klara Valko
1. Comparison of various modes and phase systems for analytical HPLC
Pavel Jandera
2. Fast-generic HPLC methods
Ian M. Mutton
3. Advances in capillary electrochromatography
Jose Luis Dores-Sousa, Jelle De Vos, Debby Mangelings and Sebastiaan Eeltink
4. Coupled chromatographyemass spectrometry techniques for the analysis of combinatorial libraries
Steve Lane
5. Experimental design-based optimization strategies for chromatographic and capillary electrophoretic separations
J. Viaene and Y. Vander Heyden
6. Computer-aided HPLC method development for quality control of complex drug mixtures--An application example for DryLab
Halina Katsialevich, Hans-Juergen Rieger, Imre Molnar and Arnold Zoeldhegyi
7. The flexible application of automated preparative purification platforms within drug discovery
Jennifer Kingston, Neil Sumner, Katie Proctor and Elisabetta Chiarparin
8. Strategies for the development of process chromatography as a unit operation for the pharmaceutical industry
Drew Katti
9. Recent developments in liquid and supercritical fluid chromatographic enantioseparations
Debby Mangelings, Sebastiaan Eeltink and Yvan Vander Heyden
10. Basis and pharmaceutical applications of thin-layer chromatography
Huba Kalasz, Maria Bathori and Klara Valko
11. Recent advances in quantitative structureeretention relationships
Roman Kaliszan
12. Capillary electrophoresis for drug analysis and physicochemical characterization
Susana Amezqueta, Xavier Subirats, Elisabet Fuguet, Clara Rafols and Marti Roses
13. Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery
Klara L. Valko
Klara Valko
1. Comparison of various modes and phase systems for analytical HPLC
Pavel Jandera
2. Fast-generic HPLC methods
Ian M. Mutton
3. Advances in capillary electrochromatography
Jose Luis Dores-Sousa, Jelle De Vos, Debby Mangelings and Sebastiaan Eeltink
4. Coupled chromatographyemass spectrometry techniques for the analysis of combinatorial libraries
Steve Lane
5. Experimental design-based optimization strategies for chromatographic and capillary electrophoretic separations
J. Viaene and Y. Vander Heyden
6. Computer-aided HPLC method development for quality control of complex drug mixtures--An application example for DryLab
Halina Katsialevich, Hans-Juergen Rieger, Imre Molnar and Arnold Zoeldhegyi
7. The flexible application of automated preparative purification platforms within drug discovery
Jennifer Kingston, Neil Sumner, Katie Proctor and Elisabetta Chiarparin
8. Strategies for the development of process chromatography as a unit operation for the pharmaceutical industry
Drew Katti
9. Recent developments in liquid and supercritical fluid chromatographic enantioseparations
Debby Mangelings, Sebastiaan Eeltink and Yvan Vander Heyden
10. Basis and pharmaceutical applications of thin-layer chromatography
Huba Kalasz, Maria Bathori and Klara Valko
11. Recent advances in quantitative structureeretention relationships
Roman Kaliszan
12. Capillary electrophoresis for drug analysis and physicochemical characterization
Susana Amezqueta, Xavier Subirats, Elisabet Fuguet, Clara Rafols and Marti Roses
13. Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery
Klara L. Valko