
Droplets of Life
Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation
Vladimir N. Uversky(Editor)
Academic Press
Published on 11. November 2022
Book
Paperback/Softback
728 pages
978-0-12-823967-4 (ISBN)
Description
Droplets of Life: Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation provides foundational information on the biophysics, biogenesis, structure, functions, and roles of membrane-less organelles. The study of liquid-liquid phase separation has attracted a lot of attention from disciplines such as cell biology, biophysics, biochemistry, and others trying to understand how, why, and what roles these condensates play in homeostasis and disease states in living organisms. This book's editor recruited a group of international experts to provide a current and authoritative overview of all aspects associated with this exciting area.
Sections introduce membrane-less organelles (MLOs) and biomolecular condensates; MLOs in different sizes, shapes, and composition; and the formation of MLOs due to phase separation and how it can tune reactions, organize the intracellular environment, and provide a role in cellular fitness.
.
Sections introduce membrane-less organelles (MLOs) and biomolecular condensates; MLOs in different sizes, shapes, and composition; and the formation of MLOs due to phase separation and how it can tune reactions, organize the intracellular environment, and provide a role in cellular fitness.
.
More details
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
College/higher education
Product notice
Paperback (trade)
Unsewn / adhesive bound
Illustrations
100 illustrations (50 in full color); Illustrations
Dimensions
Height: 235 mm
Width: 191 mm
Weight
1520 gr
ISBN-13
978-0-12-823967-4 (9780128239674)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions

Vladimir N. Uversky
Droplets of Life
Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation
E-Book
11/2022
Academic Press
€175.00
Available for download
Person
Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his PhD from Moscow Institute of Physics and Technology and D.Sc. from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences. Since 2010, Professor Uversky has worked at University of South Florida, where he works on various aspects of protein intrinsic disorder phenomenon and analysis of protein folding and misfolding processes. He has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He also servs as an editor in a number of scientific journals.
Editor
Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States
Content
Part I: Introduction to Membrane-less Organelles and Biomolecular Condensates
1. Biophysical Principles of Liquid-Liquid Phase Separation
2. Major Structural Features of MLOs
3. Multiphase Complex Droplets
4. Biogenesis of MLOs and Protein Condensates
5. Techniques for the Detection and Analysis of LLPS and MLOs
6. LLPS and Origin of Life
Part II: Biology of Membrane-Less Organelles
1. Known Types of Membrane-Less Organelles and Biomolecular Condensates
2. Active Regulation Mechanisms
3. Control of Metabolic Pathways
4. Interactions and Interplay with Classical Membrane-Bound Organelles
5. LLPS and Chromatin Organization
6. MLOs and Cellular Fitness
7. Cellular Stress
8. Phase Separation in Bacteria
9. Phase Separation and Virus Replication Compartments
Part III: Pathological roles of LLPS
1. Neurodegenerative Diseases
2. Cancer
3. Cardiovascular Diseases
4. Infectious Diseases
1. Biophysical Principles of Liquid-Liquid Phase Separation
2. Major Structural Features of MLOs
3. Multiphase Complex Droplets
4. Biogenesis of MLOs and Protein Condensates
5. Techniques for the Detection and Analysis of LLPS and MLOs
6. LLPS and Origin of Life
Part II: Biology of Membrane-Less Organelles
1. Known Types of Membrane-Less Organelles and Biomolecular Condensates
2. Active Regulation Mechanisms
3. Control of Metabolic Pathways
4. Interactions and Interplay with Classical Membrane-Bound Organelles
5. LLPS and Chromatin Organization
6. MLOs and Cellular Fitness
7. Cellular Stress
8. Phase Separation in Bacteria
9. Phase Separation and Virus Replication Compartments
Part III: Pathological roles of LLPS
1. Neurodegenerative Diseases
2. Cancer
3. Cardiovascular Diseases
4. Infectious Diseases