Growth Factors in Perinatal Development

This volume examines the molecular and cellular mechanisms by which growth factors stimulate fetal and perinatal growth, and explores the use of biotechnology-derived growth factor therapies in preventing and treating perinatal growth disorders. Included are studies on the bone morphogenetic proteins and their role in skeletal formation; the molecular basis of growth hormone action; the autocrine, paracrine, and endocrine actions of peptide growth factors such as insulin-like growth factor-1 (IGF-1); and the role of early response genes in cell growth and differentiation. Full consideration is given to the use of recombinant IGF-1, recombinant hematopoietic growth factors, and other growth factor therapies for perinatal development disorders and blood diseases, as well as for complications resulting from immature organ development.
 
This volume examines the molecular and cellular mechanisms by which growth factors stimulate fetal and perinatal growth, and explores the use of biotechnology-derived growth factor therapies in preventing and treating perinatal growth disorders. Included are studies on the bone morphogenetic proteins and their role in skeletal formation; the molecular basis of growth hormone action; the autocrine, paracrine, and endocrine actions of peptide growth factors such as insulin-like growth factor-1 (IGF-1); and the role of early response genes in cell growth and differentiation. Full consideration is given to the use of recombinant IGF-1, recombinant hematopoietic growth factors, and other growth factor therapies for perinatal development disorders and blood diseases, as well as for complications resulting from immature organ development.