
Increasing the Therapeutic Ratio of Radiotherapy
Humana (Publisher)
Published on 27. June 2018
Book
Paperback/Softback
VIII, 280 pages
978-3-319-82201-3 (ISBN)
Description
Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy.
In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.
Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).
Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.
Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).
Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
More details
Series
Edition
Softcover reprint of the original 1st ed. 2017
Language
English
Place of publication
Cham
Switzerland
Publishing group
Springer International Publishing
Target group
Professional and scholarly
Illustrations
7 s/w Abbildungen, 34 farbige Abbildungen
VIII, 280 p. 41 illus., 34 illus. in color.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 16 mm
Weight
441 gr
ISBN-13
978-3-319-82201-3 (9783319822013)
DOI
10.1007/978-3-319-40854-5
Schweitzer Classification
Other editions
Additional editions

Philip J. Tofilon | Kevin Camphausen
Increasing the Therapeutic Ratio of Radiotherapy
Book
11/2016
Humana
€160.49
Shipment within 10-15 days
Persons
Philip J. Tofilon, Ph.D., is Senior Investigator, Radiation Oncology Branch, National Cancer Institute. Kevin Camphausen, MD, is Branch Chief, Senior Investigator, Radiation Oncology Branch, National Cancer Institute.
Content
Part 1. Molecular Targets.- 1. Improving the therapeutic ratio of radiotherapy by targeting the DNA Damage Response.- 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity.- 3. Histone Deacetylase Inhibitors and Tumor Radiosensitization.- 4. Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy.- Part 2. Microenvironment.- 5. Application of Functional Molecular Imaging in Radiation Oncology.- 6. Remodeling the Irradiated Tumor Microenvironment: The 5th R of Radiobiology?.- 7. Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation.- Part 3. Clinical.- 8. Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules.- 9. Novel Imaging for Treatment Planning or Tumor Response.- 10. Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles.- Index.