Methods to Assess DNA Damage and Repair

This volume is concerned with a subject basic to chemical risk assessment: DNA damage and repair, taking account of interspecies differences. It evaluates current knowledge of the mechanisms of the activation and detoxication of DNA damaging agents, organotropic and cell-structure effects, induction and repair of DNA damage, and the molecular and phenotypical analysis of mutation induction. The report includes general recommendations aimed at improving research in this field and developing methodologies for genotoxicity testing, taking account of the potentials and limitations of available animal models.