
Methods to Assess DNA Damage and Repair
Interspecies Comparisons
Wiley (Publisher)
Published on 11. April 1994
Book
Hardback
300 pages
978-0-471-94256-6 (ISBN)
Description
This volume is concerned with a subject basic to chemical risk assessment: DNA damage and repair, taking account of interspecies differences. It evaluates current knowledge of the mechanisms of the activation and detoxication of DNA damaging agents, organotropic and cell-structure effects, induction and repair of DNA damage, and the molecular and phenotypical analysis of mutation induction. The report includes general recommendations aimed at improving research in this field and developing methodologies for genotoxicity testing, taking account of the potentials and limitations of available animal models.
More details
Series
Language
English
Place of publication
Chichester
United Kingdom
Publishing group
John Wiley and Sons Ltd
Target group
Professional and scholarly
Illustrations
index
Dimensions
Height: 235 mm
Width: 155 mm
Weight
560 gr
ISBN-13
978-0-471-94256-6 (9780471942566)
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Schweitzer Classification
Content
JOINT REPORT: Introduction, General Conclusions and Recommendations; DNA Damage; CONTRIBUTED CHAPTERS: DNA Adducts and their Consequences; Nucleotide Excision-Repair Among Species; DNA Repair in Specific Sequences and Genomic Regions; Molecular Analysis of Mutations in Shuttle Vectors and Transgenic Animals.