Bridging Bench to Bedside in Fetal and Neonatal Brain Injury
Special Topic Issue: Developmental Neuroscience 2007, Vol. 29, No. 4-5
1st Edition
Published on 30. August 2007
Book
Paperback/Softback
138 pages
978-3-8055-8319-0 (ISBN)
Description
The immature brain is vulnerable to prenatal and postnatal stresses, which may produce brain damage leading to neurological dysfunction in survivors. This special issue presents new in-sights into the detection, pathophysiology and treatment of developmental brain injuries. Importantly, several papers in this issue report pre-clinical tests of new therapies that prevent injury to the developing brain including erythropoietin, insulin-like growth factor- 1 peptides and antioxidants. New insights into how to promote brain repair from neural stem cells is also reported. Information obtained from MRI on human infants, combined with data from several animal models, highlights the effects of hypoxia-ischemia interaction, excitotoxicity, oxidative stress, seizures and inflammation on the outcome of developmental brain injury and ultimate neurological outcome.
This publication is recommended to both clinicians and basic scientists, who are interested in the developing nervous system, its vulnerability to various pathophysiological processes, and the eventual consequences for neurological development.
This publication is recommended to both clinicians and basic scientists, who are interested in the developing nervous system, its vulnerability to various pathophysiological processes, and the eventual consequences for neurological development.
More details
Edition
1st Edition 2007
Language
English
Place of publication
Basel
Switzerland
Target group
Professional and scholarly
This publication is recommended to both clinicians and basic scientists, who are interested in the developing nervous system, its vulnerability to various pathophysiological processes, and the eventual consequences for neurological development.
Illustrations
in Color:16 Tables:8
Weight
440 gr
ISBN-13
978-3-8055-8319-0 (9783805583190)
Schweitzer Classification
Content
Preface: Levison, S.W.; Tan, S.; Perinatal Brain Damage Causation: Dammann, O.; Leviton, A.; Serial Diffusion Tensor Imaging Detects White Matter Changes That Correlate with Motor Outcome in Premature Infants: Drobyshevsky, A.; Bregman, J.; Storey, P.; Meyer, J.; Prasad, P.V.; Derrick, M.; MacKendrick, W.; Tan, S.; Delayed IGF-1 Administration Rescues Oligodendrocyte Progenitors from Glutamate-Induced Cell Death and Hypoxic-Ischemic Brain Damage: Wood, T.L.; Prenatal Cord Clamping in Newborn Macaca nemestrina: A Model of Perinatal Asphyxia: Juul, S.E.; Aylward, E.; Richards, T.; McPherson, R.J.; Kuratani, J.; Burbacher, T.M.; Erythropoietin Enhances Long-Term Neuroprotection and Neurogenesis in Neonatal Stroke: Gonzalez, F.F.; McQuillen, P.; Chang, Y.; Wendland, M.; Vexler, Z.; Ferriero, D.M.; Perinatal Hypoxic/Ischemic Brain Injury Induces Persistent Production of Striatal Neurons from Subventricular Zone Progenitors: Yang, Z.; Levison, S.W.; Uteroplacental Inflammation Results in Blood Brain Barrier Breakdown, Increased Activated Caspase 3 and Lipid Peroxidation in the Late Gestation Ovine Fetal Cerebellum: Hutton, L.C.; Castillo-Melendez, M.; Walker, D.W.; Identification of POSH2, a Novel Homologue of the c-Jun N-Terminal Kinase Scaffold Protein POSH: Wilhelm, M.; Kukekov, N.V.; Xu, Z.; Greene, L.A.; Pomegranate Polyphenols and Resveratrol Protect the Neonatal Brain against Hypoxic-Ischemic Injury: West, T.; Atzeva, M.; Holtzman, D.M.; Mast Cell Stabilization Limits Hypoxic-Ischemic Brain Damage in the Immature Rat: Jin, Y.; Silverman, A.-J.; Vannucci, S.J.; Gender-Dependent Pathways of Hypoxia-Ischemia-Induced Cell Death and Neuroprotection in the Immature P3 Rat: Nijboer, C.H.A.; Kavelaars, A.; van Bel, F.; Heijnen, C.J.; Groenendaal, F.; Delayed Peripheral Administration of a GPE Analogue Induces Astrogliosis and Angiogenesis and Reduces Inflammation and Brain Injury following Hypoxia-Ischemia in the Neonatal Rat: Svedin, P.; Guan, J.; Mathai, S.; Zhang, R.; Wang, X.; Gustavsson, M.; Hagberg, H.; Mallard, C.; Antioxidant Status Alters Levels of Fas-Associated Death Domain-Like IL-1B-Converting Enzyme Inhibitory Protein following Neonatal Hypoxia-Ischemia: Payton, K.S.E.; Sheldon, R.A.; Mack, D.W.; Zhu, C.; Blomgren, K.; Ferriero, D.M.; Northington, F.J.