Disorders of Hemoglobin
Genetics, Pathophysiology, and Clinical Management
Published on 18. December 2000
Book
Hardback
1282 pages
978-0-521-63266-9 (ISBN)
Description
The first comprehensive reference on the genetic and acquired disorders of hemoglobin in over a decade, Disorders of Hemoglobin stands out as the definitive work on the genetics, pathophysiology, and clinical management of this wide-range of disorders. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the absolute world authorities on the science and clinical management of thalassemias, sickle cell disease, and other inherited and acquired hemoglobinopathies to create the authoritative textbook for researchers and clinicians alike. Divided into eight distinct sections, coverage spans the molecular and genetic basis of hemoglobinopathies and thalassemias, their epidemiology and genetic selection, and the diagnosis and special treatments of b and a thalassemias, sickle cell disease, Hb E, unstable hemoglobins, Hb M disorders, and acquired and secondary disorders of hemoglobin. Clinical features of all disorders are anchored to the scientific and pathophysiological events which precede them; providing clinicians with a clear scientific background of the disorders they treat and scientists with an essential link between their research and its clinical manifestation. Disorders of Hemoglobin is the only single-source reference of its kind for hematologists, internists, pediatricians, clinical investigators, and geneticists worldwide.
Reviews / Votes
'The first chapter sets the stage by providing a comprehensive historical perspective. The high quality of the book continues from there ... this book will be invaluable to experts in the field and extremely useful to medical students and house officers who want a single resource in which to review the clinical aspects of hemoglobin disorders.' New England Journal of Medicine 'Disorders of Hemoglobin provides a comprehensive review of both the scientific and the clinical aspects of human erythropoiesis and its disorders. It offers a collection of well written chapters by leading international investigators, many of whom are able to refer to the contribution their own research work has made to the field ... comprehensive, detailed and well written ... a fine and accessible text that can be recommended for students, scientists and clinicians who seek detailed reviews of red-cell disorders and their clinical management.' Journal of the Royal Society of Medicine 'The fact that a book of this size and scope is devoted to a single protein is an indication of the wondrous complexity of biology and a harbinger of what still lies ahead ... it is a superb exposition of current knowledge, and I am very happy to have a copy on my shelf.' OncologyMore details
Language
English
Place of publication
Cambridge
United Kingdom
Target group
Professional and scholarly
Illustrations
143 Tables, unspecified; 34 Plates, color; 88 Halftones, unspecified; 268 Line drawings, unspecified
Dimensions
Height: 288 mm
Width: 226 mm
Thickness: 60 mm
Weight
3750 gr
ISBN-13
978-0-521-63266-9 (9780521632669)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Martin H. Steinberg | Bernard G. Forget | Douglas R. Higgs
Disorders of Hemoglobin
Genetics, Pathophysiology, and Clinical Management
Book
08/2009
2nd Edition
Cambridge University Press
€575.50
Article exhausted; check different version
Persons
Content
Foreword; Introduction; 1. Historical aspects; Part I. Molecular, Cellular, and Genetic Basis of Hemoglobin Disorders: 2. Developmental erythropoiesis; 3. Erythropoiesis; 4. Nuclear factors that regulate erythropoiesis; 5. Organization, evolution and regulation of the globin genes; 6. Molecular genetics of human globin genes; 7. Molecular and cellular basis of hemoglobin switching; 8. Hemoglobin synthesis and translational control; 9. Hemoglobin structure and function; 10. Hemoglobins of the embryo and fetus and minor hemoglobins of adults; Part II. The b Thalassemias: 11. Pathophysiology of b thalassemia; 12. Molecular mechanisms of b thalassemia; 13. Clinical aspects of b thalassemia; 14. Structural variants with a b thalassemic phenotype; 15 Deletion HPFH and the delta-b thalassemias; Part III. The a Thalassemias: 16. Pathophysiology of the a thalassemias; 17. Molecular mechanisms of a thalassemia; 18. Clinical and laboratory features of the a thalassemia syndromes; 19. a Thalassemia mental retardation syndromes; Part IV. Sickle Cell Disease: 20. Pathophysiology of sickle cell anemia; 21. Red cell membrane in sickle cell disease; 22. Cellular adherence in sickle cell disease; 23. Sickle hemoglobin polymerization; 24. Clinical aspects of sickle cell anemia in adults and children; 25. The nature and treatment of the acute pain episode; 26. Genetic variability in sickle cell anemia; 27. Hb SC and Hb C disease; 28. Other sickle hemoglobinopathies; 29. Sickle cell trait; Part V. Epidemiology and Genetic Selection of Hemoglobinopathies and Thalassemia: 30. Balanced polymorphism in sickle cell disease and thalassemia-malaria; 31. Worldwide distribution of b thalassemia; 32. Worldwide distribution of a thalassemia; 33. Geographic heterogeneity of sickle cell anemia; Part VI. Diagnosis and Special Treatments for Sickle Cell Anemia and b Thalassemia Introduction: 34. Laboratory diagnosis, animal models; 35. DNA-based diagnosis of hemoglobin disorders; 36. Antenatal diagnosis, neonatal screening, population screening; 37. Transfusion and iron chelation in sickle cell disease and thalassemia; 38. Pharmacologic treatment of sickle cell disease and thalassemia; 39. Bone marrow transplantation in b thalassemia; 40. Bone marrow transplantation in sickle cell anemia; 41. Prospects for gene therapy in sickle cell disease and thalassemia; 42. Experimental treatment of sickle cell anemia and thalassemia; Part VII. Other Inherited Disorders: 43. Hb E disorders; 44. Unstable hemoglobins, hemoglobins with altered O2 affinity, Hb M; 45. Other mutant hemoglobins; Part VIII. Acquired Disorders of Hemoglobin: 46. Acquired and secondary disorders of hemoglobin.