Biomarkers in Cancer Screening and Early Detection

List of Contributors, ix Preface, xiii Part I Foundations of Biomarker Research 1 Nuts and Bolts of Biomarker Research, 3 Sharmistha Ghosh and Sudhir Srivastava 2 Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16 Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi 3 MicroRNA Biomarkers for Early Detection of Cancer, 27 WendyWang, Matthew R Young, and Sudhir Srivastava 4 Inflammation and Cancer, 37 Pamela L Beatty, Sandra Cascio, and Olivera J Finn 5 Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50 Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava 6 Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64 Elisa CWoodhouse and Suresh Mohla Part II State-of-the-Science in Organ-Specific Biomarker Research 7 Breast Cancer, 77 Benjamin A Katchman, Christos Patriotis, and Karen S Anderson 8 Ovarian Cancer, 93 Christos Patriotis, Archana Simmons, Karen H Lu, Robert C Bast, Jr, and Steven J Skates 9 Esophageal Cancer Biomarkers, 104 Yanxin Luo, Kishore Guda, SanfordD Markowitz, Amitabh Chak, Andrew M Kaz, andWilliam M Grady 10 Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118 Heath D Skinner, Qiongrong Chen, Elena Elimova, RoopmaWadhwa, Shumei Song, and Jaffer A Ajani 11 Pancreatic Cancer, 130 Sam CWang and Peter J Allen 12 Colon Cancer, 141 Paul DWagner 13 Prognostic and Predictive Biomarkers for Colorectal Cancer, 151 Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava 14 Early Detection of Lung Cancer, 163 Mohamed Hassanein, Melinda C Aldrich, Stephen A Deppen, Karl E Krueger, Eric L Grogan, and Pierre P Massion 15 Commonalities in Lung Cancer and COPD, 185 MalgorzataWojtowicz and Eva Szabo 16 Prostate Cancer, 197 Jacob Kagan, Ian M Thompson, and DanielWChan Part III Biomarkers, Screening and Precision Health: Implications for Public Health 17 Improving the Clinical Validity of Biomarker Research in Cancer Detection, 209 David F Ransohoff 18 Cancer Overdiagnosis, Ramifications and Research Strategies, 220 Barbara K Dunn and Barnett S Kramer 19 Predictive Markers and Driver Genes From Treatment Trials: Potential Utility For Early Diagnosis, 231 Brian S Sorg, Sarfraz Memon, Kelly Y Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C McKee, Barbara A Conley, and J Milburn Jessup 20 Statistical Consideration in Predictive and Prognostic Markers, 245 Fei Ye and Yu Shyr 21 Clinical Validation of Molecular Biomarkers in Translational Medicine, 256 Harry B Burke and William E Grizzle 22 Cancer Biomarker Assays: Performance Standards, 267 Anna K Fuzery and Daniel W Chan 23 Bioethics and Cancer Biomarker Research, 277 Nathan Nobis, William Grizzle, and Stephen Sodeke 24 Colon Cancer Screening, 283 Molly Perencevich, Jennifer Inra, and Sapna Syngal