Animal Cell Biotechnology: Volume 5
Published on 1. July 1992
Book
Hardback
313 pages
978-0-12-657555-2 (ISBN)
Description
The Animal Cell Biotechnology series provides an in-depth state-of-the art coverage of a field which has developed into a multi-billion dollar industry over the last ten years. Written by leading experts, each volume contains well-referenced, fully-indexed reviews on practical and theoretical aspects of a specific subject, including:
Bioreactor design and development
Cell products and their development
Downstream processing
Product testing
The main theme of this volume - applications of animal cells - has been broadened from the recurring theme of production of biologicals to the cells themselves as a product, and cells as a pharmacological/toxicological assay system. The need to replace animals in research and for the testing of drugs, foods and cosmetics is becoming increasingly critical as society has succeeded in making this a high profile ethical issue. It is the perceived belief that the best chance of reducing the use of animals will be to develop suitable assays based on cells in culture. Two chapters in this volume cover replacement animal cells and the use of skin cells for in vitro testing. Other chapters also detail the cell products tPA, Factor VIII, and Growth Factors.
The basic tool is, of course, the cell and the text contains chapters on how to standardize the cell and process in order to achieve reproducible conditions, whether for production or assay purposes. Also featured is a review of immortalization techniques that can be used to construct new cell lines which fulfill the specialized criteria required of them. Finally a chapter on surface active agents is included.
Bioreactor design and development
Cell products and their development
Downstream processing
Product testing
The main theme of this volume - applications of animal cells - has been broadened from the recurring theme of production of biologicals to the cells themselves as a product, and cells as a pharmacological/toxicological assay system. The need to replace animals in research and for the testing of drugs, foods and cosmetics is becoming increasingly critical as society has succeeded in making this a high profile ethical issue. It is the perceived belief that the best chance of reducing the use of animals will be to develop suitable assays based on cells in culture. Two chapters in this volume cover replacement animal cells and the use of skin cells for in vitro testing. Other chapters also detail the cell products tPA, Factor VIII, and Growth Factors.
The basic tool is, of course, the cell and the text contains chapters on how to standardize the cell and process in order to achieve reproducible conditions, whether for production or assay purposes. Also featured is a review of immortalization techniques that can be used to construct new cell lines which fulfill the specialized criteria required of them. Finally a chapter on surface active agents is included.
More details
Series
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Weight
630 gr
ISBN-13
978-0-12-657555-2 (9780126575552)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Persons
Jonathan Griffiths, University of Lincoln, UK
Content
R.E. Spier, Animal Cell Biotechnology in the 90s: from Models to Morals. C. MacDonald, Isolation of New Animal Cell Lines Using Immortalization Techniques. A. Doyle and J.B. Griffiths, Standardization of Animal Cell Culture Processes. D.J. Benford, The Use of Animal Cells as Replacements for Whole Animals in the Toxicity Testing of Chemicals and Pharmaceuticals. B. Coulomb and L. Dubertret, Production and Use of Skin Cell Cultures for the in Vitro Testing of Chemicals and Pharmaceuticals. A. Burt and D.A. McGrouther, The Production and Use of Skin Cell Cultures in Therapeutic Situations. F.L.J. van Lier, J.M. Vlak, and J. Tramper, Production of Baculovirus-Expressed Proteins from Suspension Cultures of Insect Cells. A.J. Beale, The Production of Viruses for Human Vaccines from Animal Cells in Culture. A.J. MacLeod, Production of Therapeutic Plasma Proteins Using Recombinant Mammalian Cells; The Example of Coagulation Factor VIII. T. Cartwright, Production of tPA from Animal Cell Cultures. P. Collodi and D.W. Barnes, Production of Growth Stimulating Factors from Animal Cells. A. Handa-Corrigan, S. Zang, and R. Brydges, Surface Active Agents in Animal Cell Cultures. Index.