The Inflammatory Ecosystem and Inflammazones
Mapping the Complex Terrain of Inflammatory Diseases
Will be published approx. on 30. September 2026
Book
Paperback/Softback
850 pages
978-0-443-45723-4 (ISBN)
Description
The Inflammatory Ecosystem and Inflammazones: Mapping the Complex Terrain of Inflammatory Diseases offers a groundbreaking framework for understanding inflammation across multiple spatial and molecular levels. The book introduces the concept of distinct inflammazones-local, regional, distal, and systemic-and explores how their interactions influence disease development, progression, and resolution. This holistic approach integrates cellular, molecular, microbiome, and systemic responses, addressing a critical gap in current knowledge and advancing diagnostics and therapies for diseases like autoimmunity and cancer. The book is organized into six sections, starting with foundational principles and progressing through mechanisms of local, regional, and systemic inflammazones.
It covers key components such as cytokines, chemokines, immune cells, and the roles of non-immune cells like fibroblasts and epithelial cells. The final sections focus on systems-level insights, including inflammaging, metabolism, and multi-omics technologies, culminating in strategies for personalized medicine and clinical translation. Each chapter combines cutting-edge research with clinical relevance, making complex concepts accessible and actionable.
It covers key components such as cytokines, chemokines, immune cells, and the roles of non-immune cells like fibroblasts and epithelial cells. The final sections focus on systems-level insights, including inflammaging, metabolism, and multi-omics technologies, culminating in strategies for personalized medicine and clinical translation. Each chapter combines cutting-edge research with clinical relevance, making complex concepts accessible and actionable.
More details
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Product notice
Paperback (trade)
Unsewn / adhesive bound
Dimensions
Height: 235 mm
Width: 191 mm
Weight
449 gr
ISBN-13
978-0-443-45723-4 (9780443457234)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Erwei Song is a Professor of Breast Surgery at Sun Yat-sen University (SYSU), Member of the Chinese Academy of Sciences, and President of Sun Yat-sen Memorial Hospital. He received his M.D. and Ph.D. from Zhongshan Medical School and trained at Harvard Medical School, where his groundbreaking study on siRNA was recognized by Science as a top 2003 breakthrough. A pioneer of breast-conserving surgery in China, Prof. Song developed the "Theory of Tumor Ecosystem,? advancing cancer immunotherapy. His research has uncovered new immune and stromal cell types, receptors, and regulatory RNAs, offering novel therapeutic targets. He has published 156 SCI papers, including in Nature, Cell, and Cancer Cell, with over 12,000 citations. He serves on editorial boards of major journals and has received top honors such as the National Innovation Award and TWAS Award. Prof. Song also led the creation of China's first breast-conserving surgery guidelines.
Phei Er Saw is a distinguished researcher at Sun Yat-sen Memorial Hospital's Medical Research Center, Sun Yat-sen University, China. She earned her PhD in Bio-Nano Medicine from the Korea Advanced Institute of Science and Technology and completed postdoctoral training at Harvard Medical School. In 2018, she joined Sun Yat-sen University through the "Hundred Talents Program," focusing on nanomedicine and tumor immunotherapy. Prof. Saw has published 100 papers, accumulating over 8,500 citations. She has recently proposed conceptual advances on tumor ecosystem, stem cell mimicry, and inflammazones in inflammatory skin diseases.
Phei Er Saw is a distinguished researcher at Sun Yat-sen Memorial Hospital's Medical Research Center, Sun Yat-sen University, China. She earned her PhD in Bio-Nano Medicine from the Korea Advanced Institute of Science and Technology and completed postdoctoral training at Harvard Medical School. In 2018, she joined Sun Yat-sen University through the "Hundred Talents Program," focusing on nanomedicine and tumor immunotherapy. Prof. Saw has published 100 papers, accumulating over 8,500 citations. She has recently proposed conceptual advances on tumor ecosystem, stem cell mimicry, and inflammazones in inflammatory skin diseases.
Content
SECTION I: Foundations of Inflammation
1. Introduction to inflammation
2. The inflammatory ecosystem: An overview
SECTION II: Local and Regional Inflammazones
3. Local inflammazone: Solid-like signalosomes
4. Local inflammazone: Liquid phase separation
5. Local inflammazones: Granuloma
6. Regional inflammazone: Lymph nodes
7. Dendritic cells in interzonal communication
SECTION III: Distal and Systemic Inflammazones
8. Distal inflammazones: Organ-specific inflammation
9. Interzonal communicators: Exosomes of immune cells
10. Systemic inflammazones: Low to high grade inflammation
11. Systemic inflammazone: The endothelium
12. Systemic inflammazone: Viruses in inflammatory diseases
13. Systemic inflammazone: Gut microbiome in inflammatory diseases
14. Systemic inflammazone: Skin microbiome in inflammatory diseases
15. Systemic inflammazone: Lung microbiome in inflammatory diseases
16. Systemic inflammazone: Vaginal microbiome and inflammatory diseases
17. Systemic inflammazone: Urinary microbiome
SECTION IV: Cellular and Molecular Components of Inflammation
18. Components in inflammatory diseases: Cytokines
19. Components in inflammatory diseases: Chemokines
20. Components in inflammatory diseases: ROS
21. Immune cells: Macrophage - friends or foes?
22. Immune cells: Neutrophils
23. Immune cells: Basophils in inflammatory diseases
24. Immune cells: Eosinophils in inflammatory diseases
25. Immune cells: Mast cells in inflammatory diseases
26. Immune cells: T cells in inflammatory diseases
27. Immune cells: B cells and plasma cells in inflammatory diseases
28. Non-immune cells: Fibroblasts in inflammation
29. Non-immune cells: Platelets in inflammation
30. Non-immune cells: Stem cells in inflammation
31. Non-immune cells: Epithelial cells in inflammation
SECTION V: Systems-level Insights in Inflammation
32. Inflammaging, senescence and inflammation
33. Metabolism and inflammation
34. Resolution of inflammation
35. Multi-omics in diagnosis of chronic inflammation
36. Subtyping in inflammatory diseases
37. Emerging biomarkers in inflammatory diseases
38. Genetics and epigenetics in inflammatory diseases
39. Environmental and biological factors in Inducing Inflammation
SECTION VI: Clinical Applications and Future Directions
40. Precision medicine delivering therapeutics
41. Clinical integration: a summary of inflammatory ecosystem
1. Introduction to inflammation
2. The inflammatory ecosystem: An overview
SECTION II: Local and Regional Inflammazones
3. Local inflammazone: Solid-like signalosomes
4. Local inflammazone: Liquid phase separation
5. Local inflammazones: Granuloma
6. Regional inflammazone: Lymph nodes
7. Dendritic cells in interzonal communication
SECTION III: Distal and Systemic Inflammazones
8. Distal inflammazones: Organ-specific inflammation
9. Interzonal communicators: Exosomes of immune cells
10. Systemic inflammazones: Low to high grade inflammation
11. Systemic inflammazone: The endothelium
12. Systemic inflammazone: Viruses in inflammatory diseases
13. Systemic inflammazone: Gut microbiome in inflammatory diseases
14. Systemic inflammazone: Skin microbiome in inflammatory diseases
15. Systemic inflammazone: Lung microbiome in inflammatory diseases
16. Systemic inflammazone: Vaginal microbiome and inflammatory diseases
17. Systemic inflammazone: Urinary microbiome
SECTION IV: Cellular and Molecular Components of Inflammation
18. Components in inflammatory diseases: Cytokines
19. Components in inflammatory diseases: Chemokines
20. Components in inflammatory diseases: ROS
21. Immune cells: Macrophage - friends or foes?
22. Immune cells: Neutrophils
23. Immune cells: Basophils in inflammatory diseases
24. Immune cells: Eosinophils in inflammatory diseases
25. Immune cells: Mast cells in inflammatory diseases
26. Immune cells: T cells in inflammatory diseases
27. Immune cells: B cells and plasma cells in inflammatory diseases
28. Non-immune cells: Fibroblasts in inflammation
29. Non-immune cells: Platelets in inflammation
30. Non-immune cells: Stem cells in inflammation
31. Non-immune cells: Epithelial cells in inflammation
SECTION V: Systems-level Insights in Inflammation
32. Inflammaging, senescence and inflammation
33. Metabolism and inflammation
34. Resolution of inflammation
35. Multi-omics in diagnosis of chronic inflammation
36. Subtyping in inflammatory diseases
37. Emerging biomarkers in inflammatory diseases
38. Genetics and epigenetics in inflammatory diseases
39. Environmental and biological factors in Inducing Inflammation
SECTION VI: Clinical Applications and Future Directions
40. Precision medicine delivering therapeutics
41. Clinical integration: a summary of inflammatory ecosystem