Multimodality Therapy für Head and Neck Cancer
Published in April 1992
Book
Hardback
VIII, 188 pages
978-3-13-778801-0 (ISBN)
Description
This book assists oncologists towards a better understanding of the management of patients with advanced head and neck cancer and provides a stimulus and guide for the essential interdisciplinary approach required of all surgical and non-surgical specialists involved in oncology. The first part of the book is an overview of squamous cell carcinoma of the head and neck (SCCHN). The natural history, prognostic factors, evaluation and staging are reviewed. The principles of single-modality treatment, surgery and radiotherapy are discussed, emphasizing their limitations and indicating areas in which advances of each of these modalities might be expected. Much attention is given to the biostatistical issues in the design and interpretation of clinical trials of SCCHN. In the second part of this book the principles and applications of the various multi-modality treatments for patients with SCCHN are reviewed. The rationale and treatment strategies of combined surgery and radiotherapy are considered and controversial areas are identified.
Multi-modality therapy with chemotherapy in its various settings - neo-adjuvant, adjuvant or synchronous radiotherapy - is critically assessed and strategies including chemotherapy which are most likely to benefit patients are indicated. Finally therapies, which are in development, such as immunobiological therapy and differentiation therapy, are reviewed.
Multi-modality therapy with chemotherapy in its various settings - neo-adjuvant, adjuvant or synchronous radiotherapy - is critically assessed and strategies including chemotherapy which are most likely to benefit patients are indicated. Finally therapies, which are in development, such as immunobiological therapy and differentiation therapy, are reviewed.
More details
Content
Part 1 Epidemiology and natural history of head and neck cancer - conventional single-modality surgery and radiotherapy (brief introduction): the developmental history of surgery and radiotherapy for head and neck cancer; principles of single-modality therapy, and general expectations of outcome, avoiding exhaustive site-specific descriptions; the failure of single-modality therapy for advanced disease; the problem of premalignant lesions, multiple primary lesions and second primary carcinomas. Part 2 Progress in the treatment of head and neck cancer will come in two forms - advances in surgery or radiotherapy and advances in multi-modality therapy: the potential "cost" of progress - mention of the potential for enhanced toxicity with aggressive surgery of radiotherapy, or multi-modality treatment; mention potential means of limiting toxicity; state-of-the-art overview of head and neck cancer - epidemiololgy and natural history of head and neck cancer, surgery for head and neck cancer; radiotherapy for head and neck cancer; statistical considerations in the design of clinical trials for head and neck cancer; multi-modality therapies - combined modality surgery and radiotherapy; multi-modality therapy with chemotherapy.