Biochemistry
J. Smiley(Author)
Blackwell Science Inc. (Publisher)
Book
Paperback/Softback
208 pages
978-0-632-04446-7 (ISBN)
Description
The "11th Hour" series of books is configured modularly and linked to a set of dedicated Web pages. These modules are designed to be used by students on science courses and provide outside assistance to students having trouble with their studies.
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
John Wiley and Sons Ltd
Target group
College/higher education
Professional and scholarly
Illustrations
20 illustrations
Dimensions
Height: 8 mm
Width: 11 mm
ISBN-13
978-0-632-04446-7 (9780632044467)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
Unit I: General and Organic Chemistry for Biochemistry; Functional groups; Groups at the ends of molecules; Groups within molecules; Applications; Spectroscopic identification of functional groups ; Protons and electrons; Acid-base chemistry; Hydrogen bonding; Resonance and tautomerism; Radicals; Nucleophilic reactions; Heteroatoms; Nucleophilic carbon; Application: Synthesis of aspirin; Transition states and high-energy intermediates; Proton transfer; sp2 - sp3 transition; Trigonal bipyramidal TS; Thermodynamics of chemical reactions; Kinetics and thermodynamics; Energy-rich compounds Unit II: Biological molecules: Building blocks and their assemblies; Amino acids, peptides and proteins; The amino acids that constitute proteins; Primary structure: peptide bonds and side chains; Secondary structure; Tertiary structure and forces that stabilize; Application: Chemical synthesis of polypeptides; Carbohydrates and polysaccharides; Chirality; Equilibrium of open chain and cyclic sugars and anomeric carbons; Glycosidic bonds; Survey of important polysaccharides; Application: Industrial conversion of sucrose to glucose and fructose; Nucleotides and nucleic acids; Purines and pyrimidines; Nucleotides comprising DNA vs. RNA; Nucleic acid structure; Interstrand base-pairing Application: DNA hybridization with radiolabeled oligonucleotide; Lipids and membranes Unit III: Biochemical reactions; A compendium of biochemical reactions; Hydrolysis; Group transfer; Isomerizations/racemizations; Oxidations/reductions; Additions/eliminations; Carbon-carbon bond making and breaking; Ligases; Glycolysis: A strategic series of reactions for production of energy-rich compounds; Glucose Fru-1,6-DiPO4: Formation of symmetric hexose diphosphate; Fru-1,6-DiPO4 2 GAP: Splitting the hexose; GAP 3PG: Oxidation and substrate-level phosphorylation; 3PG Pyr: Finessing the phosphate for more ATP; Overall energy gain from glucose 2 Pyr; Citric Acid Cycle: A cyclical series of reactions for oxidation of pyruvate; Overview of the strategy of the citric acid cycle; Input of two carbons from acetyl-CoA: oxaloacetate citrate; Rearrangement: citrate isocitrate; Two oxidative decarboxylations succinate; Oxidation of succinate oxaloacetate, the starting material; Isotope tracing experiments in the citric acid cycle; Unit IV: Quantitative aspects of Enzyme Action; Michaelis-Menten kinetics; Effects of temperature, pH, and salt on enzyme activity; Enzyme inhibition; Factors that contribute to enzyme catalysis; Acid-base reactions; Covalent (nucleophilic) reactions; Proximity; Hydrophobic effects and removal of solvent water; Transition state stabilization; Classics in enzyme mechanisms; Unit V: Metabolic pathways and cycles; Pentose phosphate pathway; Nitrogen metabolism: Urea cycle, and purine and pyrimidine biosynthesis