Respiratory Genetics
1st Edition
Published on 30. September 2005
Book
Hardback
496 pages
978-0-340-81432-1 (ISBN)
Description
There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume.
The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments.
Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.
The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments.
Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.
Reviews / Votes
"(An) excellent introduction to the topic of respiratory genetics for people moving into the field but the book will also be a valuable reference source for investigators who already have a working knowledge of the subject."I.P. Hall, Human Genetics
More details
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
College/higher education
Illustrations
150 b/w line drawings, 50 b/w halftones, 20 colour halftones
Dimensions
Height: 276 mm
Width: 210 mm
ISBN-13
978-0-340-81432-1 (9780340814321)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Edwin K Silverman, Assistant Professor of Medicine, Harvard Medical School, Boston, USA
Steven D Shapiro, Parker B. Francis Professor of Medicine, Harvard Medical School, Brigham & Womens Hospital, Boston, USA
David A Lomas, Professor, Respiratory Medicine Unit, University of Cambridge, UK
Scott T Weiss, Professor of Medicine, Harvard Medical School, Boston, USA
Steven D Shapiro, Parker B. Francis Professor of Medicine, Harvard Medical School, Brigham & Womens Hospital, Boston, USA
David A Lomas, Professor, Respiratory Medicine Unit, University of Cambridge, UK
Scott T Weiss, Professor of Medicine, Harvard Medical School, Boston, USA
Content
Part 1: Key Concepts in Respiratory Genetics
Overview of human genetics
Phenotypes for Human Respiratory Genetics
Testing for association in genetic studies
Sample Collection and Genotyping for Human Respiratory Genetics
Molecular characterization of genetic variation: sample collection and processing in human respiratory genetics
Molecular characterization of genetic variation: genetic variation, genotyping, and sequencing
Bioinformatics: public databases and SNPs
Bioinformatics: genomics and proteomics in lung disease: microarrays and bioinformatics issues
Functional genomics: clinical functional genomics
Functional genomics: expression and purification of recombinant proteins
Functional genomics: functional characterization of a protein
Functional genomics: biophysical analysis of proteins and proteinaEUR"protein interactions
Functional genomics: crystallography, nuclear magnetic resonance, and modeling
Functional genomics: functional analysis of mutant proteins in cells
Genomic physiology in animals
Pharmacogenetics
Part 2: Obstructive lung diseases
Asthma genetics
Chronic obstructive pulmonary disease
Cystic fibrosis
Part 3: Interstitial lung diseases
Idiopathic pulmonary fibrosis
Sarcoidosis
Part 4: Miscellaneous pulmonary conditions
Pulmonary hypertension
Genetics of lung cancer
Respiratory infections
Congenital, metabolic, and neuromuscular diseases
Other rare lung diseases: disorders of surfactant homeostasis
Other rare lung diseases: lymphangioleiomyomatosis
Other rare lung diseases: HermanskyaEUR"Pudlak Syndrome
Overview of human genetics
Phenotypes for Human Respiratory Genetics
Testing for association in genetic studies
Sample Collection and Genotyping for Human Respiratory Genetics
Molecular characterization of genetic variation: sample collection and processing in human respiratory genetics
Molecular characterization of genetic variation: genetic variation, genotyping, and sequencing
Bioinformatics: public databases and SNPs
Bioinformatics: genomics and proteomics in lung disease: microarrays and bioinformatics issues
Functional genomics: clinical functional genomics
Functional genomics: expression and purification of recombinant proteins
Functional genomics: functional characterization of a protein
Functional genomics: biophysical analysis of proteins and proteinaEUR"protein interactions
Functional genomics: crystallography, nuclear magnetic resonance, and modeling
Functional genomics: functional analysis of mutant proteins in cells
Genomic physiology in animals
Pharmacogenetics
Part 2: Obstructive lung diseases
Asthma genetics
Chronic obstructive pulmonary disease
Cystic fibrosis
Part 3: Interstitial lung diseases
Idiopathic pulmonary fibrosis
Sarcoidosis
Part 4: Miscellaneous pulmonary conditions
Pulmonary hypertension
Genetics of lung cancer
Respiratory infections
Congenital, metabolic, and neuromuscular diseases
Other rare lung diseases: disorders of surfactant homeostasis
Other rare lung diseases: lymphangioleiomyomatosis
Other rare lung diseases: HermanskyaEUR"Pudlak Syndrome