Textbook of Neural Repair and Rehabilitation

Part I. Neural Plasticity - Cellular and Molecular Mechanisms of Neural Plasticity: 1. Degenerative changes and reactive growth responses of neurons following denervation and axotomy: historical concepts and their modern embodiments; 2. Learning and memory: basic principles and model systems; 3. Short-term plasticity: facilitation, augmentation, potentiation and depression; 4. Long-term potentiation and long-term depression; 5. Cellular and molecular mechanisms of associative and nonassociative learning; Part II. Functional Plasticity in the Central Nervous System: 6. Plasticity of mature and developing somatosensory systems; 7. Activity-dependent plasticity in the intact spinal cord; 8. Plasticity of cerebral motor functions: implications for repair and rehabilitation; 9. Plasticity in visual connections: retinal ganglion cell axonal development and regeneration; 10. Plasticity in auditory functions; 11. Cross-modal plasticity in the visual system; Part III. Plasticity after Injury to the Central Nervous System: 12. The role of extracellular matrix in plasticity in the spinal cord; 13. Spinal plasticity underlying the recovery of locomotion after injury; 14. Cellular mechanisms of plasticity after brain lesions; 15. Pathophysiology and plasticity in cerebral palsy; 16. Noninvasive brain stimulation in cognitive rehabilitation: guiding plasticity after injury to the central nervous system; 17. From bench to bedside: influence of theories of plasticity on human neurorehabilitation; Part IV. Neural Repair - Basic Cellular and Molecular Processes: 18. Neuronal death and rescue: neurotrophic factors and anti-apoptotic mechanisms; 19. Axon degeneration and rescue; 20. Adult neurogenesis and neural precursors, progenitors, and stem cells in the adult central nervous system; 21. Axon guidance during development and regeneration; 22. Synaptogenesis; Part V. Determinants of Regeneration in the Injured Nervous System: 23. Non-mammalian models of nerve regeneration; 24. Myelin-associated axon growth inhibitors; 25. Inhibitors of axonal regeneration; 26. Glial development and their role in axon regeneration; 27. Effects of the glial scar and extracellular matrix molecules on axon regeneration; 28. The role of the inflammatory response in central nervous system injury and regeneration; 29. Neurotrophin repair of spinal cord damage; 30. Intraneuronal determinants of regeneration; Part VI. Promotion of Regeneration in the Injured Nervous System: 31. Cellular replacement in spinal cord injury; 32. Dysfunction and recovery in demyelinated and dysmyelinated axons; 33. Role of Schwann cells in peripheral nerve regeneration; 34. Transplantation of Schwann cells and olfactory ensheathing cells as a therapeutic strategy in spinal cord injury; 35. Trophic factor delivery by gene therapy; 36. Assessment of sensorimotor function after experimental spinal cord injury and repair; Part VII. Translational Research: Application to Human Neural Injury: 37. Biomimetic design of neural prostheses; 38. Brain responses to neural prostheses; 39. Brain-computer interfaces; 40. Intracranial brain-computer interfaces for communication and control; 41. Stem cell therapies for brain disorders; 42. Understanding motor recovery and compensation in neurorehabilitation; Index.