Metabolomics as a Tool in Nutrition Research

List of contributors
Woodhead Publishing Series in Food Science, Technology and Nutrition
Preface
Part One: Principles

1. Challenges in nutritional metabolomics: from experimental design to interpretation of data sets

Abstract
1.1 Introduction
1.2 The experimental design
1.3 The analytical platform
1.4 Extraction of data sets and statistical analyses
1.5 Metabolite identification
1.6 Biological interpretations
1.7 Conclusion: do we need standardisation procedures and repositories?


2. Metabolic profiling as a tool in nutritional research: key methodological issues

Abstract
2.1 Introduction
2.2 Key issues in nutritional research
2.3 The role of genomics, proteomics, metabolomics, and metagenomics in nutritional research
2.4 Applications of metabolomics in nutrition-related research
2.5 The use of metabolomics to assess the effects of diet on health
2.6 Methods for mapping dietary patterns
2.7 Observational and interventional studies into the effects of diet and nutrition on health
2.8 Analytical methods
2.9 Issues in analysing samples


3. Chemometrics methods for the analysis of genomics, transcriptomics, proteomics, metabolomics, and metagenomics datasets

Abstract
3.1 Introduction
3.2 Unsupervised and supervised pattern recognition methods
3.3 Multivariate calibration methods for developing predictive models
3.4 Statistical data integration methods
3.5 Data integration: multiblock strategies
3.6 Data integration: calibration transfer methods
3.7 Data integration: multiway/multimodal analysis methods
3.8 Data integration: correlation-based approaches
3.9 Data integration: techniques for analysing different types of genomics datasets
3.10 Statistical data integration of different sample types
3.11 Statistical data integration of different molecular components in samples
3.12 Modelling relationships between molecular components
3.13 Conclusion and future trends




Part Two: Applications in nutrition research

4. Application of lipidomics in nutrition research

Abstract
Acknowledgement
4.1 Introduction
4.2 Lipids
4.3 Lipidomics
4.4 Lipidomics in nutrition research
4.5 Conclusion and future trends


5. Analysing human metabolic networks using metabolomics: understanding the impact of diet on health

Abstract
Acknowledgements
5.1 Introduction
5.2 Metabolic network reconstruction
5.3 Human metabolic networks
5.4 Linking metabolomics data and metabolic network elements
5.5 Metabolism modelling, from pathways to network
5.6 Subnetwork extraction between identified metabolites
5.7 Conclusion and future directions


6. Using metabolomics to analyse the role of gut microbiota in nutrition and disease

Abstract
6.1 Introduction: gut microbiota and human health
6.2 Metagenomics of gut microbiota
6.3 Metabolomics: uncovering complex host-microbe interactions
6.4 The marriage of metagenomics and metabolomics: microbiome-metabolome interactions
6.5 Future perspectives: personalised nutrition


7. Metabotyping: moving towards personalised nutrition

Abstract
7.1 Introduction
7.2 The concept of the metabotype
7.3 Examples of metabotyping with a focus on nutrition
7.4 Extension of metabotypes to include markers of dietary origin
7.5 Conclusion and future trends
7.6 Sources of further information and advice


8. Using metabolomics to identify biomarkers for metabolic diseases: analytical methods and applications

Abstract
8.1 Introduction
8.2 Using metabolomics to understand the relationship between nutrition and chronic metabolic diseases
8.3 Cohort studies and biomarker identification
8.4 Isolating in situ biomarkers
8.5 Conclusions and future trends


9. Using metabolomics to evaluate food intake: applications in nutritional epidemiology

Abstract
9.1 Introduction
9.2 Biomarkers as a complementary approach to questionnaires
9.3 Definition of the food metabolome
9.4 Metabolomics as a tool for dietary biomarker discovery
9.5 Dietary patterns and metabolomic profiles: potential use of nutritypes
9.6 Validation of putative biomarkers
9.7 The future of metabolomics in dietary assessment
9.8 Conclusion


10. Metabolomics and nutritional challenge tests: what can we learn?

Abstract
10.1 Introduction
10.2 Application of metabolomics to challenge tests
10.3 Conclusion and future trends


11. Using metabolomics to describe food in detail

Abstract
11.1 Introduction
11.2 Using metabolomics to assess the effects of genetic selection and modification
11.3 Using metabolomics to assess the effects of organic versus conventional farming
11.4 Using metabolomics to identify the geographical origin of food products
11.5 Using metabolomics to assess the effects of rearing conditions on the quality of meat, eggs, and fish
11.6 Using metabolomics to assess the effects of processing on food quality
11.7 Using metabolomics to assess the effects of digestion on nutrient intake from particular foods
11.8 Conclusion
Appendix: abbreviations


12. Future perspectives for metabolomics in nutrition research: a nutritionist's view

Abstract
12.1 Introduction
12.2 Metabolites identification and biological relevance
12.3 In vivo metabolomics
12.4 Conclusion




Index