Bioreaction Engineering
Modeling and Control
Published on 21. December 2011
Book
Paperback/Softback
XL, 604 pages
978-3-642-64103-9 (ISBN)
Description
The book is intended to present various examples for reactor and process modeling and control as well as for metabolic flux analysis and metabolic design at an ad vanced level. In Part A, General principles and techniques with regard to reactor and process models, process control, and metabolic flux analysis are presented. In addition the accuracy, precision, and reliability of the measured data are discussed which are ex tremely important for process modeling and control. A virtual bioreactor system is presented as well, which can be used for the training of students and operators of industrial plants and for the development of advanced automation tools. In Part B, the General principles are applied for particular bioreactor models. It covers the application of the computational fluiddynamic (CFD) technique to stirred tank and bubble column bioreactors. Different solution methods are presented: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with an appropriate turbulence (k-ee) model, and the Euler (two fluid model), as well as the Euler-Langrange approaches.
More details
Edition
Softcover reprint of the original 1st ed. 2000
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Research
Illustrations
XL, 604 p.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 35 mm
Weight
966 gr
ISBN-13
978-3-642-64103-9 (9783642641039)
DOI
10.1007/978-3-642-59735-0
Schweitzer Classification
Other editions
Additional editions
E-Book
12/2012
Springer
€96.29
Available for download
Book
09/2000
1st Edition
Springer
€119.99
Article exhausted; check different version
Content
The Need for Modeling and Control in Biotechnical Processes.- Some Modeling Basics.- Structure and Operation of Biotechnical Plant.- References.- A General Principles and Techniques.- 1 Bioreactor Models.- 2 Bioprocess Models.- 3 Metabolic Flux Analysis.- 4 Accuracy and Reliability of Measured Data.- 5 Bioprocess Control.- 6 On-Line Simulation Techniques for Bioreactor Control Development.- B Application of General Principles for Reactor Models.- 7 Application of Computational Fluiddynamics (CFD) to Modeling Stirred Tank Bioreactors.- 8 Bubble Column Bioreactors.- C Application of General Principles for Process Models Including Control.- 9 Baker's Yeast Production.- 10 Modeling of the Beer Fermentation Process.- 11 Lactic Acid Production.- 12 Control Strategies for High-Cell Density Cultivation ofEscherichia coli.- 13 ?-Lactam Antibiotics Production withPenicillium chrysogenum and Acremonium chrysogenum.- D Metabolite Flux Analysis, Metabolic Design.- 14 Quantitative Analysis of Metabolic and Signaling Pathways inSaccharomyces cerevisiae.- 15 Metabolic Analysis ofZymomonas mobilis.- 16 Metabolic Flux Analysis ofCorynebacterium glutamicum.- 17 Analysis of Metabolic Fluxes in Mammalian Cells.