Cerebral Dysgenesis

Among physicians responsible for the care of human infants born with a malformed nervous system, there is a compelling need for an accessible synthesis and summary of modern embryological concepts of dysgenesis. This book integrates the morphological, clinical, neurological, genetic, neurophysiological and imaging aspects of cerebral malformation in the context of lucid embryological explanation. Rather than presenting a catalogue of anatomical abnormalities, the text focuses onpathogenesis and clinical aspects. Anatomical appearances are described by imaging in life, while neuropathological features are derived from findings at autopsy. Embryological explanations are identified as documented observation or speculation. The literature is exhaustively reviewed and supplementedby the author's own experience, and richly illustrated throughout.