Host-guest interactions between a drug and cyclodextrin

The effectiveness of a drug depends on its bioavailability. The general reason of low oral bioavailability is due to low solubility of drug molecules. To get, required pharmacological action it is important to have a desired concentration of drug in the solution, for which solubility is the important factor. Cyclodextrins have the ability to solubilize hydrophobic drugs which have pharmaceutical applications and crosslink to form polymers used for drug delivery. It is therefore interesting to observe the physico-chemical interactions between the drug molecule and the carrier molecule in aqueous media.