Modern Synthetic Methodologies toward Glycomimetics
Published on 3. March 2005
Book
Hardback
202 pages
978-0-8412-3880-0 (ISBN)
Description
Modern Synthetic Methodologies Toward Glycomimetics contains 10 chapters describing the syntheses of natural and non-natural glycomimetics using modern transition metal catalyzed reactions. This book also contains several experimental details allowing the readers to get familiar with such intricate reactions using complex alkylidene carbenoids, samarium diodide, dicobalt octacarbonyl alkyne cyclotrimerization, and the like. The descripitions of biologically
active carbohydrates are elegantly detailed. A new solution-phase glycopeptide synthesis using unprotected glycosyl amino acids as phase-tags is also described. Important strategies into the design of complex sialic acid C-saccharides, aryl C-glycosides, and conformationally restricted analogs of the
important sialyl Lewis X are discussed. Tethering of carbohydrate residues through ester bonds and applications of the Tebbe's methylenation and either ring closing metathesis or intramolecular C-glycosidations are used to provide novel carbohydrate analogs.
active carbohydrates are elegantly detailed. A new solution-phase glycopeptide synthesis using unprotected glycosyl amino acids as phase-tags is also described. Important strategies into the design of complex sialic acid C-saccharides, aryl C-glycosides, and conformationally restricted analogs of the
important sialyl Lewis X are discussed. Tethering of carbohydrate residues through ester bonds and applications of the Tebbe's methylenation and either ring closing metathesis or intramolecular C-glycosidations are used to provide novel carbohydrate analogs.
Reviews / Votes
The book provides outstanding chapters by a highly recognised group of researchers that will serve as a valuable tool for well-trained traditional glycochemists and particularly for newcomers in the field of glycomimetics. Current Engineering Practice, Volume 48 2005.More details
Series
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Illustrations
2 halftones, 119 line illlus.
Dimensions
Height: 236 mm
Width: 158 mm
Thickness: 15 mm
Weight
365 gr
ISBN-13
978-0-8412-3880-0 (9780841238800)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Person
Content
Preface
1: Alois Furstner: Reflections upon Olefin Metathesis in Carbohydrate Chemistry
2: Maarten H.D. Postema, Jared L. Piper, Lei Liu, Venu Komanduri, and Russell L. Betts: Synthesis of Stable Carbohydrate Mimetics
3: Chi-Chang Chen, Dino Ress, and Robert J. Linhart: Synthesis of Neu5Ac, KDN, and KDO C-Glycosides
4: Emma R. Palmacci, Holger Herzner, and Peter H. Seeberger: Synthesis of C-Glycosides with Glycosyl Phosphates
5: Kathlyn A. Parker: Aryl C-Glycosides by the Reverse Polarity Approach
6: Peter S. Belica, Alain Berthold, Nikki Charles, Guangwu Chen, Ajit Parhi, Paolo Pasetto, Jun Pu, Guangli Yang, and Richard W. Franck: The Ramberg-Backlund Way to C-Glyucosides
7: R.W. Denton, and D.R. Mootoo: Conformationally Restrained C-Glycoside Probes for Sialyl Lewis X-Selectin Recognition
8: Rene Roy, M. Corazon Trono, and Denis Giguere: Effects of Linker Rigidity and Orientation of Mannoside Clusters for Multivalent Interactions with Proteins
9: Vincent Bouvet, and Robert N. Ben: Antifreeze Glycoprotein Analogs: Synthesis, In Vitro Testing, and Applications
10: Zhongwu Guo: Unprotected Oligosaccharides as Phase Tags for Solution-Phase Glycoprotein Synthesis with Solid-Phrase Workup
Author Index
Subject Index
1: Alois Furstner: Reflections upon Olefin Metathesis in Carbohydrate Chemistry
2: Maarten H.D. Postema, Jared L. Piper, Lei Liu, Venu Komanduri, and Russell L. Betts: Synthesis of Stable Carbohydrate Mimetics
3: Chi-Chang Chen, Dino Ress, and Robert J. Linhart: Synthesis of Neu5Ac, KDN, and KDO C-Glycosides
4: Emma R. Palmacci, Holger Herzner, and Peter H. Seeberger: Synthesis of C-Glycosides with Glycosyl Phosphates
5: Kathlyn A. Parker: Aryl C-Glycosides by the Reverse Polarity Approach
6: Peter S. Belica, Alain Berthold, Nikki Charles, Guangwu Chen, Ajit Parhi, Paolo Pasetto, Jun Pu, Guangli Yang, and Richard W. Franck: The Ramberg-Backlund Way to C-Glyucosides
7: R.W. Denton, and D.R. Mootoo: Conformationally Restrained C-Glycoside Probes for Sialyl Lewis X-Selectin Recognition
8: Rene Roy, M. Corazon Trono, and Denis Giguere: Effects of Linker Rigidity and Orientation of Mannoside Clusters for Multivalent Interactions with Proteins
9: Vincent Bouvet, and Robert N. Ben: Antifreeze Glycoprotein Analogs: Synthesis, In Vitro Testing, and Applications
10: Zhongwu Guo: Unprotected Oligosaccharides as Phase Tags for Solution-Phase Glycoprotein Synthesis with Solid-Phrase Workup
Author Index
Subject Index