Infusion Chemotherapy
Irradiation Interactions - Principles and Applications to Organ Salvage and Prevention of Second Primary Neoplasms
Published on 8. December 1997
Book
Hardback
476 pages
978-0-444-82608-4 (ISBN)
Description
Scientific advances of the past quarter century have vastly expanded our knowledge and understanding of the biologic, aetiologic and molecular mechanisms responsible for neoplasia. Significant progress has been made in designing specific therapies for certain tumours, with improved outcomes. In this volume, Rosenthal and Rotman have assembled a series of chapters with a unifying theme of exploring the scientific basis of chemotherapy and irradiation therapy. Clinical significant synergistic therapeutic interactions between chemotherapy and irradiation therapy are highlighted. The reader is provided with an overview of the theoretical and experimental basis for irradiation-chemotherapy interactions in the first chapter, co-authored by the editors. Subsequent chapters address the pharmacokinetics of radiosensitizing agents, and explore the optimization of schedules for infusional therapy with concomitant radiation.
Highlights of this volume include several chapters which provide useful overviews of the newest and most promising molecular approaches to cancer treatment: apoptosis as a target of therapeutic development; use of antiangiogenesis agents in cancer treatment; gene therapy and its applications to chemo-radiation therapy of cancer; and tumour suppression gene inactivation by SV40 mediated transformation. Generalist physicians and specialists will find this text to be a useful resource that can provide answers to questions asked by patients, and that can help direct the clinician to appropriate sources for further inquiry in this most important and rapidly changing field.
Highlights of this volume include several chapters which provide useful overviews of the newest and most promising molecular approaches to cancer treatment: apoptosis as a target of therapeutic development; use of antiangiogenesis agents in cancer treatment; gene therapy and its applications to chemo-radiation therapy of cancer; and tumour suppression gene inactivation by SV40 mediated transformation. Generalist physicians and specialists will find this text to be a useful resource that can provide answers to questions asked by patients, and that can help direct the clinician to appropriate sources for further inquiry in this most important and rapidly changing field.
More details
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
College/higher education
Professional and scholarly
Illustrations
indexes
Weight
1010 gr
ISBN-13
978-0-444-82608-4 (9780444826084)
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Schweitzer Classification
Content
Foreword. Preface. List of contributors. Section I: Modulation of Radiotherapy by Biological and Chemotherapeutic Agents. Infusion chemotherapy-irradiation interactions: an overview (C.J. Rosenthal, M. Rotman). Optimal scheduling of chemo-radiotherapy regimens (J. Lokich). Retinoids and cytokines in combination with ionizing radiation in squamous cell carcinomas - preclinical and clinical results (W. Hoffmann, M. Bamberg and H.P. Rodemann). Mechanisms of interaction between 5-fluorouracil and radiation: implications for continuous infusion chemotherapy (J.E. Tepper, A.W. Blackstock). Early clinical trials using platinum compounds as radiosensitizers (E. Boven). cis-Dichlorodiammine platinum(II) given in low-dose continuous infusion with concurrent radiotherapy to patients affected by inoperable lung carcinoma: a pharmacokinetic approach (F. Morazzoni et al.). Infusional schedules of platinum compounds and 5-fluorouracil in the chemoradiotherapy of solid tumors (G. Grecchi et al.). Hypoxia directed drugs: use with irradiation (S. Rockwell). Interaction of mitomycin C by continuous intravenous infusion and radiation in the treatment of colon carcinoma metastic to the liver: evidence for a synergistic effect (C.J. Rosenthal et al.). Concurrent paclitaxel and radiation therapy for solid tumors (H. Choy). The paclitaxel module: phase I and pharmacokinetic study of 96 h paclitaxel (W.H. Wilson). Paclitaxel by protracted infusion with concomitant radiation therapy: phase I study (C.J. Rosenthalet al). Doxorubicin as radiation potentiator: concurrent doxorubicin and radiation therapy interaction and its clinical applications (L-T. Wu). Section II: Organ Salvage after Treatment with Irradiation and Concomitant Infusion Chemotherapy in Locally Advanced Malignant Tumors. Is organ salvage in advanced disease possible? (M. Tubiana). Preservation of structure and function in epidermoid cancer of the anal canal (B.J. Cummings). Infusional chemoradiation in the co