
Interleukin-1 in the Brain
Pergamon (Publisher)
Published on 26. October 1992
Book
Hardback
216 pages
978-0-08-041996-1 (ISBN)
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Description
Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors.
More details
Language
English
Place of publication
Amsterdam
Netherlands
Publishing group
Elsevier Science & Technology
Target group
College/higher education
Professional and scholarly
Dimensions
Height: 240 mm
Weight
480 gr
ISBN-13
978-0-08-041996-1 (9780080419961)
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Content
Foreword. Location of interleukin-1 in the nervous system, M. Schultzberg. Brain interleukin-1 receptors: mapping, characterization and modulation, F. Haour et al. Interleukin-1Beta activation of the central nervous system, P. E. Gottschall et al. Electrophysiological studies of the effects of Interleukin-1 and alpha-interferon on the EEG and pituitary-adrenocortical activity, D. Saphier. The immune-hypothalamo-pituitary adrenal axis: its role in immunoregulation and tolerance to self-antigens, F. Berkenbosch et al. The pyrogenic action of cytokines, C. M. Blatteis. Metabolic responses to interleukin-1, N. J. Rothwell. Behavioural effects of cytokines, R. Dantzer et al. Interleukin-1 involvement in the regulation of sleep, M. R. Opp & J. M. Kru;ger. Regulation of the synthesis of nerve growth factor ( NGF ) by interleukin-1 ( IL-1 ): facts and questions, M. Meyer et al. Cytokines and neuronal degeneration, E. E. Wollman et al. Index.