Dynamics of Bone and Cartilage Metabolism
Principles and Clinical Applications
Published on 22. July 1999
Book
Hardback
672 pages
978-0-12-634840-8 (ISBN)
Description
Dynamics of Bone and Cartilage Metabolism is a comprehensive treatise that spans the complete range from basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders.
Part I of the book provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components, including the important regulators such as cytokines, growth factors, and proteases.
The second part of the book covers the organizational structure and cellular metabolism of bone and cartilage. As with the first part, there are separate sections on bone and cartilage addressing their specific and unique functions. For bone, questions on mineralization, remodeling and hormonal regulation are covered as well as the derivation of products of metabolism: for cartilage, the physiology and pathology are reviewed in relation to the products of metabolism, together with recent data from animal and in vitro models. The first two parts of the book serve to contextualize all of the biochemical markers for assessing bone and cartilage metabolism.
Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease, both in experimental and clinical settings. A wide range of disorders affecting bone and cartilage metabolism is covered, including different forms of osteoporosis, metastatic bone disease and arthritic diseases, as well as some of the less common growth and degenerative abnormalities. This application-oriented part of the book is complemented by an initial section detailing the methodological and technical aspects of the various biochemical and genetic markers of disease and their measurements.
With contributions from over 75 international experts, this book will be indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases.
Part I of the book provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components, including the important regulators such as cytokines, growth factors, and proteases.
The second part of the book covers the organizational structure and cellular metabolism of bone and cartilage. As with the first part, there are separate sections on bone and cartilage addressing their specific and unique functions. For bone, questions on mineralization, remodeling and hormonal regulation are covered as well as the derivation of products of metabolism: for cartilage, the physiology and pathology are reviewed in relation to the products of metabolism, together with recent data from animal and in vitro models. The first two parts of the book serve to contextualize all of the biochemical markers for assessing bone and cartilage metabolism.
Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease, both in experimental and clinical settings. A wide range of disorders affecting bone and cartilage metabolism is covered, including different forms of osteoporosis, metastatic bone disease and arthritic diseases, as well as some of the less common growth and degenerative abnormalities. This application-oriented part of the book is complemented by an initial section detailing the methodological and technical aspects of the various biochemical and genetic markers of disease and their measurements.
With contributions from over 75 international experts, this book will be indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases.
Reviews / Votes
"The close developmental and spatial relation between bone and cartilage is self-evident, yet these two issues are often considered as separate entities. The approach taken in theis book--to consider the structural, functional, metabolic, and pathologic aspects of bone and cartilage in parallel--is a welcome departure and provides the reader with an unusual and interesting range of topics... Scientists and physicians who wish to cross the divide between bone and cartilage will find this book of considerable interest and value. There is excellent coverage of the structural and physiologic characteristics of these tissues and detailed descriptions of the methods involved in assessing tissue markers of metabolism in body fluids."--Juliet E. Compston, University of Cambridge, UK, in THE NEW ENGLAND JOURNAL OF MEDICINE (April 20, 2000)
More details
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Dimensions
Height: 279 mm
Width: 216 mm
Weight
1900 gr
ISBN-13
978-0-12-634840-8 (9780126348408)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Markus J. Seibel | Simon P. Robins | John P. Bilezikian
Dynamics of Bone and Cartilage Metabolism
Principles and Clinical Applications
Book
10/2006
2nd Edition
Academic Press
€271.50
Shipment within 15-20 days
Persons
John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Markus J Seibel, MD PhD FRACP FAHMS, is Professor of Endocrinology at Sydney Uni?versity. He is the Inaugural Director of the Bone Research Program at the ANZAC Research Institute, and heads the Department of Endocrinology & Meta?bolism at Concord Hospital, Sydney. His research in musculoskeletal biology covers topics such as glucocorticoid signalling in bone and its effects on bone and systemic fuel metabolism and ageing; the biology of bone metastases; and the clinical efficacy of secondary fracture prevention programs. Prof Seibel has published over 400 scientific papers and is the editor of 8 books. In 2017, he has been elected to the Australian Academy of Health and Medical Sciences. Prof Seibel is a Past President of the Australia and New Zealand Bone & Mineral Society (ANZBMS), a Member of the Board of Directors, International Federation of Musculoskeletal Research Societies (IFMRS), and the Chair of the Australian National Alliance for Secondary Fracture Prevention.
Author
Rowett Research Institute, Aberdeen, U.K.
Columbia University, New York, New York, U.S.A.
Editor
Concord Hospital, University of Sydney, Australia; Director, Department of Endocrinology and Metabolism, Concord Hospital Medical Center; Professor and Chair of Endocrinology, The University of Sydney
Content
K. von der Mark, Structure and Biosynthesis of Collagens.
S.P. Robins, Fibrillogenesis and Maturation of Collagens.
C.M. Gundberg and K. Nishimoto, Vitamin K Dependent Proteins of Bone and Cartilage.
D. Heinegard, T. Saxne, and P. Lorenzo, Non-Collagenous Proteins: Glycoproteins and Related Molecules.
T.E. Hardingham, Proteoglycans and Glycosaminoglycans.
G. Russell and P. Croucher, Regulatory Components: Growth Factors.
L. Raisz and J. Lorenzo, Cytokines and Prostaglandins.
M.H. Helfrich and M.A. Horton, Integrins and Adhesion Molecules.
P. Henthorn, P. Leboy, and J.L. Millan, Acid and Alkaline Phosphatases.
I.M. Clark and G. Murphy, Matrix Proteases.
A.L. Boskey, Mineralization, Structure, and Function of Bone.
J.B. Lian and G. Stein, The Cells of Bone.
L.A. Fitzpatrick and J.P. Bilezikian, Parathyroid Hormone.
D. Goltzman and A.C. Karaplis, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: PTHrP: Of Molecules, Mice, and Men.
R. Bouillon, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Vitamin D.
S. Khosla and B.L. Riggs, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Sex and Steroid Effects on Bone Metabolism.
R. Rizzoli and J.-P. Bonjour, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology of Calcium and Phosphate Homeostasis.
D.W. Dempster, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: New Concepts in Bone Remodeling.
J. Risteli and L. Risteli, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Bone Collagen Metabolism.
P. Bruckner and E.F. Eikenberry, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Supramolecular Structure of Cartilage Matrix.
M.T. Bayliss, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology and Pathology of Cartilage Metabolism.
D.-H. Manicourt, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Cartilage Metabolism.
P.A. Simkin, Fluid Dynamics of the Joint Space Trafficking of Matrix Breakdown Products.
H.J. Haeuselmann, In Vitro Models of Cartilage Metabolism.
R.D. ALtman and C.J. Lozada, Animal Models of Cartilage Breakdown.
H.A.P. Pols, J.P.T.M. van Leeuwen, and A.G. Uitterlinden, Genetic Approaches to Metabolic Bone Disease.
H. Schmidt-Gayk, Measurement of Local and Systemic Regulators of Bone Metabolism.
R. Eastell and K.E. Naylor, Measurement of Biochemical Markers of Bone Formation.
M.E. Kraenzlin and M.J. Seibel, Measurement of Biochemical Markers of Bone Resorption.
E.F. Eriksen and K. Brixen, Validation of Local and Systematic Markers of Bone Turnover.
S. Gay, M. Neidhart, and R.E. Gay, Genetic Markers of Joint Disease.
E.J. Thonar, M.E. Lenz, K. Masuda, and D.-H. Manicourt, Markers of Cartilage Metabolism.
P.J. Delmas and P. Garnero, Postmenopausal Osteoporosis.
C. Rosen, Age-Related Osteoporosis.
E.S. Orwoll, Osteoporosis in Men.
I.R. Reid, Steroid Induced Osteoporosis.
E. Shane, Secondary Osteoporosis.
M.K. Drezner, Osteomalacia and Rickets.
K.J. Martin and E.A. Gonzalez, Renal Osteodystrophy.
S.J. Silverberg and J.P. Bilezikian, Primary Hyperparathyroidism.
A. Grauer and E.S. Siris, Paget's Disease of Bone.
J.-J. Body, Metastatic Bone Disease.
M.P. Whyte, Rare Bone Diseases.
S.R. Goldring and M.B. Goldring, Rheumatoid Arthritis and Other Inflammatory Joint Pathologies.
K. Akesson, Osteoarthritis and Degenerative Spine Pathologies.
J.M. Gertner, Normal and Abnormal Growth and Development.
S.P. Robins, Fibrillogenesis and Maturation of Collagens.
C.M. Gundberg and K. Nishimoto, Vitamin K Dependent Proteins of Bone and Cartilage.
D. Heinegard, T. Saxne, and P. Lorenzo, Non-Collagenous Proteins: Glycoproteins and Related Molecules.
T.E. Hardingham, Proteoglycans and Glycosaminoglycans.
G. Russell and P. Croucher, Regulatory Components: Growth Factors.
L. Raisz and J. Lorenzo, Cytokines and Prostaglandins.
M.H. Helfrich and M.A. Horton, Integrins and Adhesion Molecules.
P. Henthorn, P. Leboy, and J.L. Millan, Acid and Alkaline Phosphatases.
I.M. Clark and G. Murphy, Matrix Proteases.
A.L. Boskey, Mineralization, Structure, and Function of Bone.
J.B. Lian and G. Stein, The Cells of Bone.
L.A. Fitzpatrick and J.P. Bilezikian, Parathyroid Hormone.
D. Goltzman and A.C. Karaplis, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: PTHrP: Of Molecules, Mice, and Men.
R. Bouillon, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Vitamin D.
S. Khosla and B.L. Riggs, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Sex and Steroid Effects on Bone Metabolism.
R. Rizzoli and J.-P. Bonjour, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology of Calcium and Phosphate Homeostasis.
D.W. Dempster, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: New Concepts in Bone Remodeling.
J. Risteli and L. Risteli, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Bone Collagen Metabolism.
P. Bruckner and E.F. Eikenberry, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Supramolecular Structure of Cartilage Matrix.
M.T. Bayliss, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology and Pathology of Cartilage Metabolism.
D.-H. Manicourt, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Cartilage Metabolism.
P.A. Simkin, Fluid Dynamics of the Joint Space Trafficking of Matrix Breakdown Products.
H.J. Haeuselmann, In Vitro Models of Cartilage Metabolism.
R.D. ALtman and C.J. Lozada, Animal Models of Cartilage Breakdown.
H.A.P. Pols, J.P.T.M. van Leeuwen, and A.G. Uitterlinden, Genetic Approaches to Metabolic Bone Disease.
H. Schmidt-Gayk, Measurement of Local and Systemic Regulators of Bone Metabolism.
R. Eastell and K.E. Naylor, Measurement of Biochemical Markers of Bone Formation.
M.E. Kraenzlin and M.J. Seibel, Measurement of Biochemical Markers of Bone Resorption.
E.F. Eriksen and K. Brixen, Validation of Local and Systematic Markers of Bone Turnover.
S. Gay, M. Neidhart, and R.E. Gay, Genetic Markers of Joint Disease.
E.J. Thonar, M.E. Lenz, K. Masuda, and D.-H. Manicourt, Markers of Cartilage Metabolism.
P.J. Delmas and P. Garnero, Postmenopausal Osteoporosis.
C. Rosen, Age-Related Osteoporosis.
E.S. Orwoll, Osteoporosis in Men.
I.R. Reid, Steroid Induced Osteoporosis.
E. Shane, Secondary Osteoporosis.
M.K. Drezner, Osteomalacia and Rickets.
K.J. Martin and E.A. Gonzalez, Renal Osteodystrophy.
S.J. Silverberg and J.P. Bilezikian, Primary Hyperparathyroidism.
A. Grauer and E.S. Siris, Paget's Disease of Bone.
J.-J. Body, Metastatic Bone Disease.
M.P. Whyte, Rare Bone Diseases.
S.R. Goldring and M.B. Goldring, Rheumatoid Arthritis and Other Inflammatory Joint Pathologies.
K. Akesson, Osteoarthritis and Degenerative Spine Pathologies.
J.M. Gertner, Normal and Abnormal Growth and Development.