Molecular Neuropathology
Published on 8. June 1995
Book
Paperback/Softback
199 pages
978-0-521-42558-2 (ISBN)
Description
This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.
More details
Series
Language
English
Place of publication
Cambridge
United Kingdom
Target group
Professional and scholarly
Product notice
Paperback (trade)
Illustrations
5 Tables, unspecified; 8 Halftones, unspecified; 26 Line drawings, unspecified
Dimensions
Height: 247 mm
Width: 173 mm
Thickness: 11 mm
Weight
412 gr
ISBN-13
978-0-521-42558-2 (9780521425582)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Content
Part I. Basic Techniques: 1. Brain banks M. C. Royston and M. Stefan; 2. RNA isolation and analysis M. S. Palmer; 3. Polymerase chain reaction M. S. Palmer; 4. Principles and practice of in situ hybridization histochemistry in neuropsychiatric research P. J. Harrison and R. C. A. Pearson; 5. Immunocytochemistry - a neuropathological perspective S. M. Gentleman and G. W. Roberts; 6. Autoradiography in brain research M. C. Royston; Part II. Applications: 7. Human prion disease M. S. Palmer and J. Collinge; 8. Molecular pathogenesis of the cerebral amyloidosis G. W. Roberts, M. Gentleman and J. McKenzie; 9. Intracerebral transplantation and functional recovery H. F. Baker and R. Ridley; 10. Methods of construction of transgenic animals and applications of the technology F. Busfield, K. Duff, C. Lendon and A. Goate; 11. Neuropathology by numbers: application of image analysis techniques to quantitative neuropathology M. C. Royston.