
The Mast Cell
A Multifunctional Effector Cell
Domenico Ribatti(Author)
Springer (Publisher)
Published on 30. July 2019
Book
Hardback
VII, 112 pages
978-3-030-24189-6 (ISBN)
Description
Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in thecontext of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.
More details
Edition
2019 ed.
Language
English
Place of publication
Cham
Switzerland
Publishing group
Springer International Publishing
Target group
Professional and scholarly
Illustrations
4 s/w Abbildungen, 8 farbige Abbildungen
VII, 112 p. 12 illus., 8 illus. in color.
Dimensions
Height: 241 mm
Width: 160 mm
Thickness: 12 mm
Weight
376 gr
ISBN-13
978-3-030-24189-6 (9783030241896)
DOI
10.1007/978-3-030-24190-2
Schweitzer Classification
Other editions
Additional editions

Book
08/2020
Springer
€106.99
Shipment within 7-9 days

E-Book
07/2019
1st Edition
Springer
€96.29
Available for download
Person
The author, Domenico Ribatti, Full professor of the University of Bari, is an expert in the field of Mast Cells with more than 800 publications.
Content
Foreword.- Mast cell ontogeny.- Staining of mast cells.- Mast cells heterogeneity.- Mast cell biology and functions.- Mast cells in arteriogenesis.- Mast cells in primary systemic vasculitides.- Mast cells in blood-brain barrier alterations and neurodegenerative diseases.- Mast cells and basophils: a link between angiogenesis and inflammation in allergic diseases.- Mast cells in tumor fate.- Mast cells in tumor angiogenesis and lymphoangiogenesis.- Mast cells as therapeutic target in cancer.- Index.