Genomic Imprinting
Published on 1. November 1997
Book
Hardback
268 pages
978-0-19-963626-6 (ISBN)
Description
Genomic imprinting, the differential marking of genes inherited from paternal and maternal sources, has been recognized since the late 1970s and is known to be involved in several inherited diseases. However, it is only very recently that questions surrounding the mechanisms of genomic imprinting have begun to be answered. This volume reviews the latest exciting developments, with full citations of all of the key bibliography. It also discusses the major unanswered questions in this field and outlines directions for future research. This book is intended for post-graduate and post-doctoral researchers and academic staff.
More details
Language
English
Place of publication
Oxford
United Kingdom
Target group
College/higher education
Professional and scholarly
Illustrations
9 halftones, 62 line figures, bibliography
ISBN-13
978-0-19-963626-6 (9780199636266)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Persons
Content
Role of DNA methylation in mammalian development; developmental regulation of imprinting by DNA methylation; imprinting at the mouse and human IGF2R loci; function and epigenetic modification of the imprinted H19 gene; the imprinted insulin-like growth factor 2 gene; consequences of genomic imprinting for foetal development; genomic imprinting in the mouse - possible final analysis; systematic approaches for the identification of imprinted genes; genomic imprinting as a developmental process disturbed in cancer; imprinting in the Prader-Willi/Angelman syndrome region on human chromosome 15; convergent themes in X chromosome inactivation and autosomal imprinting; evolutionary theories of genomic imprinting.