Genomic Imprinting
Published on 11. September 1997
Book
Paperback/Softback
268 pages
978-0-19-963625-9 (ISBN)
Description
Genomic imprinting, the differential marking of genes inherited from paternal and maternal sources, has been recognized since the late 1970s and is known to be involved in several inherited diseases. However, it is only very recently that questions surrounding the mechanisms of genomic imprinting have begun to be answered. This volume reviews the latest exciting developments, with full citations of all of the key bibliography. It also discusses the major unanswered
questions in this field and outlines directions for future research. Topics covered in Genomic Imprinting include: the role of DNA methylation in mammalian development; developmental regulation of imprinting by DNA methylation; imprinting at the mouse and human IGF2R loci; function and epigenetic
modification of the imprinted H19 gene; the imprinted insulin-like growth factor 2 gene; consequences of genomic imprinting for fetal development; genomic imprinting in the mouse; systematic approaches for the identification of imprinted genes; genomic imprinting as a developmental process disturbed in cancer; imprinting in the PraderWilli/Angelman syndrome region on human chromosome 15; convergent themes in X chromosome inactivation and autosomal imprinting; and evolutionary theories of
genomic imprinting.
questions in this field and outlines directions for future research. Topics covered in Genomic Imprinting include: the role of DNA methylation in mammalian development; developmental regulation of imprinting by DNA methylation; imprinting at the mouse and human IGF2R loci; function and epigenetic
modification of the imprinted H19 gene; the imprinted insulin-like growth factor 2 gene; consequences of genomic imprinting for fetal development; genomic imprinting in the mouse; systematic approaches for the identification of imprinted genes; genomic imprinting as a developmental process disturbed in cancer; imprinting in the PraderWilli/Angelman syndrome region on human chromosome 15; convergent themes in X chromosome inactivation and autosomal imprinting; and evolutionary theories of
genomic imprinting.
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Target group
Professional and scholarly
Illustrations
halftones, line figures, tables
Dimensions
Height: 245 mm
Width: 190 mm
Thickness: 15 mm
Weight
600 gr
ISBN-13
978-0-19-963625-9 (9780199636259)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Dr Wolf Reik, The Babraham Institute, Babraham Hall, Babraham, Cambridge CB2 4AT. Email: wolf.reik@bbsrc.ac.uk
Professor Azim Surani, Wellcome/CRC Institute, Cambridge
Professor Azim Surani, Wellcome/CRC Institute, Cambridge
Content
Role of DNA methylation in mammalian development ; Developmental regulation of imprinting by DNA methylation ; Imprinting at the mouse and human IGF2R loci ; Function and epigenetic modification of the imprinted H19 gene ; The imprinted insulin-like growth factor 2 gene ; Consequences of genemoic imprinting for fetal development ; Genomic imprinting in the mouse: possible final analysis ; Systematic approaches for the identification of imprinted genes ; Genomic imprinting as a developmental process disturbed in cancer ; Imprinting in the Prader-Willi/Angelman syndrome region on human chromosome 15 ; Convergent themes in X chromosome inactivation and autosomal imprinting ; Evolutionary theories of genomic imprinting