Topological Data Analysis for Genomics and Evolution

Reviews / Votes

'The time is right to bring new approaches to the analysis of biological data. Topological data analysis reveals the structure of data. This book shows how algebraic topology opens new doors, presenting ideas and directions that make testable predictions and explore life processes.' Arnold J. Levine, Institute for Advanced Study, New Jersey 'This fascinating book describes how advances in mathematics, especially in fields such as topology, are transforming our understanding of biology. Rabadan, one of the founders of the field, shows us how the evolution of cancer, and of viruses and bacteria, can be deeply understood through these novel mathematical techniques. Rabadan's capacity to create a synthesis of many threads, and lay out future challenges, makes this an intriguing and compelling read.' Siddhartha Mukherjee, Columbia University Medical Center, New York and author of The Gene: An Intimate History and The Emperor of All Maladies: A Biography of Cancer 'This is a very important work that shows the way to applications of topological data analysis in genomics. It should be studied carefully by anyone working on the biomedical applications of topological data analysis.' Gunnar Carlsson, Stanford University, California 'This is an important book. Modern experimental biology produces large amounts of data and of many disparate types, requiring new methods of analysis. In explaining biology to mathematicians and data scientists, and subtle new statistical analyses based on the flexible form of geometry called topology to biologists, carefully and clearly, without sacrificing accuracy, the authors have written a unique book that is cutting edge, truly interdisciplinary, and a resource for both communities. I found it fascinating, and will insist that my students read it.' Shmuel Weinberger, Andrew MacLeish Distinguished Service Professor of Mathematics, University of Chicago '... has been a useful strategy, it is ill-equipped to deal with the very high dimensionality of genomic data. The book will be of interest to biologists and mathematicians ranging from advanced undergraduates to experienced researchers seeking to add new analytic strategies in their work, or to establish collaborations across disciplines.' D. P. Genereux, Choice 'The book works well for mathematicians who want to understand how some basic ideas from topology can be applied to the study of data from problems in biology ... It is convenient to have all of the necessary background in a single publication ... the volume succeeds in being a stepping stone between a textbook and a survey article in an exciting new field' Terence Gaffney, The Quarterly Review of Biology