A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.
Reviews / Votes
From the reviews:
"...an outstanding book for those who want a concise review of platelet function and its relevance to thrombotic disorders and current pharmacology." - Circulation
"...a very useful book for anyone interested in the fundamentals of platelet function, platelet biomarkers, techniques for activation measurement, and thrombotic disorders." - Circulation
"This book is directed to the attention of clinicians practicing clinical and or laboratory medicine, basic scientists interested in platelet physiology, pharmocologists focusing on cardiovascular drugs, and teachers of medical students and physicians in training. . The most advanced investigative techniques are presented in separate chapters to explore platelet membrane receptors, signal-dependant translation in platelets and for identifying products that regulate thrombosis and inflammation. . a relatively small book, but with 397 pages of pertinent and practical knowledge from major professionals in the field." (Harry L. Messmore and William H. Wehrmacher, Clinical and Applied Thrombosis/Hemostasis, Vol. 12 (1), January, 2006)
Series
Edition
Softcover reprint of hardcover 1st ed. 2005
Language
Place of publication
Target group
Professional and scholarly
Research
Illustrations
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 26 mm
Weight
ISBN-13
978-1-61737-447-0 (9781617374470)
DOI
10.1007/978-1-59259-917-2
Schweitzer Classification
Platelet Physiology.- Platelet Physiology.- Platelet Integrins and Signaling.- Platelet Adhesion.- Structure-Function of the Platelet Cytoskeleton.- Platelets and Inflammation.- Platelet Signal-Dependent Protein Synthesis.- Phosphoproteomics of Human Platelets.- Assessing Platelet Function.- Platelet Function Studies.- Platelet Function Under Flow.- Pharmacodynamics of GPIIb-IIIa Receptor Blockade.- Prostanoid Generation in Platelet Function.- Platelets and Prothrombin.- Markers of Platelet Activation and Granule Secretion.- Genomic and Proteomic Analysis of Platelets.- Clinical Applications.- Antiplatelet Agents.- Assessing Platelet Function in Clinical Trials.
