Oncogenes in B-Cell Neoplasia
Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 5-7, 1984
Published on 10. December 2011
Book
Paperback/Softback
XIII, 268 pages
978-3-642-69862-0 (ISBN)
Description
Michael Potter, Fritz Melchers, Martin Weigert The second workshop on Mechanisms of B Cell Neoplasia was held in Bethesda, Maryland in Wilson Hall at the National Institutes of Health on March 5, 6, and 7, 1984. It followed a workshop on the same topic that was held at the Basel Institute for Immunology, March 15-17, 1983. That first meeting attempted to bring together cell biologists, experimental pathologists and molecular geneti- cists interested in B cells, to discuss pathogenetic processes in the development and maintenance of the neoplastic state. The impetus for this discussion emanated from two important developments: first, the discovery of the viral promoter insertion mechanism for acti- vating the myc oncogene in bursal lymphomatosis by Hayward, Neil, and Astrin;-second, the findings that the non-random chromosomal trans locations involving the immunoglobulin gene chromosomes occur- red in very high frequencies in murine plasmacytomas and human Burkitt's lymphomas. During the planning stages of that meeting Shen-Ong et al. discovered that non-random translocations activated the myc oncogene.
Promoter insertions and non-random trans locations were-rwo mechanisms that caused transcription of the myc oncogene messages in three different kinds of well defined experimental and clinical B cell tumors. Unregulated myc gene transcription provided the first evidence of a specific bioChemical lesion in B cell neo- plasia.
Promoter insertions and non-random trans locations were-rwo mechanisms that caused transcription of the myc oncogene messages in three different kinds of well defined experimental and clinical B cell tumors. Unregulated myc gene transcription provided the first evidence of a specific bioChemical lesion in B cell neo- plasia.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1984
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Research
Illustrations
XIII, 268 p.
Dimensions
Height: 244 mm
Width: 170 mm
Thickness: 16 mm
Weight
502 gr
ISBN-13
978-3-642-69862-0 (9783642698620)
DOI
10.1007/978-3-642-69860-6
Schweitzer Classification
Other editions
Additional editions
M. Potter | F. Melchers | M. Weigert
Oncogenes in B-Cell Neoplasia
Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 5-7, 1984
Book
08/1984
1st Edition
Springer
€117.69
Article exhausted; check different version
Content
Cooperation of Oncogenes in B-Cell Neoplasia.- Introductory Remarks.- Activated Oncogenes in Burkitt's Lymphoma.- Detection of an Adenovirus E1A-like Activity in Mammalian Cells.- Does the Large T Protein of Polyoma Virus Regulate the Expression of the Celluar myc Gene?.- Genome Structure and Host Range Restriction of the Lymphotropic Papovavirus (LPV): Identification of a Viral Lymphocyte Specific Enhancer Element.- Tlym-I, a Stage Specific Transforming Gene Shares Homology with MHC I Region Genes.- Structural and Functional Analysis of ras and Blym Oncogenes.- Structural Organization of Mouse emyb Locus and the Mechanism of its Rearrangement in ABPL-2 Tumor Line Induced by Pristane and Abelson Murine Leukemia Virus.- Disruption and Activation of the c-myb Locus by M-MuLV Insertion in Plasmacytoid Lymphosarcomas Induced by Pristane and Abelson Viruses.- Follicular Hyperplasia in the Prelymphomatous Avian Bursa, Relationship to the Incidence of B-Cell Lymphomas.- Growth Factors in B-Cell Neoplasia.- Multiple Steps in the Transformation of Normal B Cells Towards Neoplasia.- Transferrin Receptors Regulate Proliferation of Normal and Malignant B Cells.- Cloned Neoplastic B Cells Release a Growth Factor Which Augments Lymphokine-Mediated Proliferation of Normal B Cells.- The Action of an Lyb2.1-Specific Monoclonal Antibody in Soluble or Immobilized Form on Resting and Activated B Cells.- T Cell Factors Regulating B Cell Activation and Differentiation.- Interleukin 3 Dependent Retrovirus Induced Lymphomas: Loss of the Ability to Terminally Differentiate in Response to Differentiation Factors.- Growth Regulation of a B-Cell Lymphoma via the Antigen Receptor.- Interleukin-2 Receptors on Activated Malignant and Normal B-Cells.- Immuno Affinity Purified Interleukin 2 (IL2)Induces B Cell Growth.- Factors Affecting Normal and Malignant B Lymphocyte Precursors.- Immunoglobulin Heavy Chain Switching in Cultured I.29 Murine B Lymphoma Cells: Commitment to an IgA or IgE Switch.- Regulation of myc Gene Expression in Normal and Neoplastic Cells.- The Regulation of c-myc by Growth Signals.- Immune Regulation of the c-myc Oncogene in a Murine B Lymphoma.- The Translocated c-myc Oncogene of Burkitt Lymphoma is Differentially Regulated in Lymphoblastoid vs Plasma Cells.- Mechanism of myc Gene Activation.- Modes of c-myc Oncogene Activation in Murine Plasmacytomas.- DNA Sequences Involved in the Rearrangement and Expression of the Murine c-myc Gene.- Activation of the c-myc Oncogene in B and T Lymphoid Tumors.- The c-myc Gene Paradox in Burkitt's Lymphoma Chromosomal Translocation.- Amplification, Expression, and Rearrangement of c-myc and N-myc Oncogenes in Human Lung Cancer.- Chromosomal Aberrations in Murine Plasmacytomas.- Chromatin Structural Changes in the Putative Regulatory Region of c-myc Accompany the Translocation in a Burkitt Lymphoma.- Aberrant Rearrangements at the Murine Light Chain Locus in Plasmacytomas.- The myc Gene Product.- myc-Encoded Proteins of Chickens and Men.- Properties of the myc-Gene Product: Nuclear Association, Inhibition of Transcription and Activation in Stimulated Lymphocytes.- In Vitro Culture of B Lymphocytes.- to Long-Term Cultures of Normal B Lymphocytes.- Characteristics of Continuous in vitro Lines of BALB/c and NZB B Cells.- Development of Cells of the B-Lymphocyte Lineage in Longterm Culture.- Coexpression of Lyb-2 and Mac-1by Murine Lymphomas and Subpopulations of Normal Spleen and Bone Marrow Cells.- Ly-1 as a Differentiation Antigen on Normal and Neoplastic B Cells.- Propagation of B Lymphocytes inVitro.- Potential New Systems for the Generation of B Cell Tumors.- Identification of a Transforming Virus from a Lymphoma of a Mouse Infected with a Wild Mouse Retrovirus.- Transformation Capacities of a Murine Retrovirus Encoding an Avian myc Oncogene.- The CH Series of Murine B Cell Lymphomas: Identification of Cross-reactive Idiotypes and Restricted Antigen Specificities.- Interaction of Acute Transforming Retroviruses with Murine Hematopoietic Cells.- Monoclonal Antibody to Abelson Lymphoma Cells.