Translational Aspects of Extracellular Matrix
Book
Paperback/Softback
336 pages
978-0-12-802836-0 (ISBN)
Description
Translational Aspects of Extracellular Matrix offers a foundation for understanding ECM in relation to other fields. Beginning with ECM formation and function, then focusing on therapeutics approaches and targeting ECM in the clinic, this publication is a reference for researchers of all levels with diverse backgrounds. With chapters edited and written by experts in ECM research, this publication integrates broad concepts to translational research and offers readers guidance as a starting point for further literature study.
More details
Series
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Dimensions
Height: 229 mm
Width: 152 mm
ISBN-13
978-0-12-802836-0 (9780128028360)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Persons
Professor Pihlajaniemi is obtained the Anders Jahre's Nordic Medical Prize for Young Scientists in 1994 and the Science Prize of the State of Finland (shared) in 1999. She is professor and chairman of Medical Biochemistry and Molecular Biology at Oulu University and her current research interests include the cell-extracellular matrix interplay in physiological and pathological situations involving transmembrane collagens and the endostatin collagen. Professor Myllyharju is the director of Biocenter Oulu since 2010, having previously served as the Vice-Director of the Institue of Biomedicine at the University of Oulu. She has gained a formiddable reputation in the research fields of extracellular matrix proteins, collagens and hypoxia.
Editor
Professor and Chairman of Medical Biochemistry and Molecular Biology, Collagen Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland
Scientific Director of Biocenter Oulu Professor, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland
Content
Part I: Distinct Types of Matrices and Their Biological Significance
Fibrillar matrices
Basement membranes
Bone
Brain ECM
Part II: Featured Molecular Entities, Their Functions and Therapeutic Approaches
Adhesive structures, overview on integrins and others
Proteoglycans
Anti-angiogenesis and ECM molecules
Matricryptins
Hyaluronans
ECM degradation
Cell niche and cell signaling
ECM interactome
Post-translational modifications of ECM molecules
Laminins
Part III: Abnormal Functions of the ECM and Therapeutic Approaches
Osteogenesis imperfecta
Cartilage pathologies and therapeutic approaches
Collagen IV diseases
Skin diseases and therapeutic approaches
Muscle diseases
Fibrosis
Microfibrillar disorders
ECM and metabolism
ECM and the immune system
ECM and malignant progression
ECM and tissue engineering/regenerative medicine
Fibrillar matrices
Basement membranes
Bone
Brain ECM
Part II: Featured Molecular Entities, Their Functions and Therapeutic Approaches
Adhesive structures, overview on integrins and others
Proteoglycans
Anti-angiogenesis and ECM molecules
Matricryptins
Hyaluronans
ECM degradation
Cell niche and cell signaling
ECM interactome
Post-translational modifications of ECM molecules
Laminins
Part III: Abnormal Functions of the ECM and Therapeutic Approaches
Osteogenesis imperfecta
Cartilage pathologies and therapeutic approaches
Collagen IV diseases
Skin diseases and therapeutic approaches
Muscle diseases
Fibrosis
Microfibrillar disorders
ECM and metabolism
ECM and the immune system
ECM and malignant progression
ECM and tissue engineering/regenerative medicine