Environmental Mutagenesis
Published in December 1995
Book
Hardback
256 pages
978-1-872748-19-1 (ISBN)
Description
This volume critically examines current methods for detecting and identifying mutagens in the environment. It describes the molecular mechanisms of mutagenesis, and assesses the involvement of mutagens in cancer and inherited disease. Full details are provided on all the major in vivo and in vitro methods of mutagenicity testing, including fluorescence in situ hybridization, the use of genetically engineered cells, and transgene technology.
More details
Series
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
College/higher education
Professional and scholarly
Illustrations
47ill.44tabs.
Dimensions
Height: 234 mm
Width: 156 mm
ISBN-13
978-1-872748-19-1 (9781872748191)
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Schweitzer Classification
Content
The importance of environmental mutagens in human carcinogenesis and germline mutation, D.H. Phillips and S. Venitt; role of mutagenesis and mitogenesis in carcinogenesis, J.C. Barrett; molecular mechanisms of mutagenesis and mutational spectra, B.W. Glickman et al; inherited susceptibility to mutation, D.G. Harnden; pharmacogenetic polymorphisms, G. Smith et al; mutagenicity tests in bacteria as indicators of carcinogeneric potential in mammals, E. Zeiger; in vitro cytogenetics and aneuploidy, E.M. Parry and J.M. Parry; in vivo assays for mutagenicity, J. Heddle; in vivo germ cell mutagenicity assays, J.B. Bishop and K.L. Witt; mouse spot test, R. Fahrig; mammalian cell mutation assays, D. Clive; assays for unscheduled DNA synthesis in vivo, J.C. Mirsalis; use of genetically engineered cells for genetic toxicology testing, C.L. Crespi; fluorescence in situ hybridization - application to environmental mutagenesis, D.A. Eastmond and D.S. Rupa; measuring genetic events in transgenic animals, R. Forster; the single cell/comet assay, R.R. Tice; human monitoring for somatic mutation in humans, R.J. Albertini and J.P. O'Neill; DNA and adducts as biomarkers of exposure to environmental mutagens, D.H. Phillips and P.B. Farmer.