Comparative Genetic Toxicology
(the Second Ukems Collaborative Study)
Published on 31. December 1986
Book
Hardback
XIII, 626 pages
978-3-527-26435-3 (ISBN)
Description
This collection of 69 papers investigates 'in vitro' metabolic activation preparations for two specific pairs of chemical analogues, benzidine (BZD) with 4,4-diaminoterphenyl (DAT) and 4-dimethyl-aminoazobenzene (DAB) with 4-cyanodimethylaniline (CDA). The preparations selected were uninduced rat liver (using rats of the same strain as the bioassay). Aroclor-induced rat liver, uninduced mouse liver (using the same mouse strain as used in the 'in vivo' cytogenetics assays), and uninduced chicken. The major bulk of the assays described in the study involved the use of large common batches of these 59 preparations. The study was sponsored by the United Kingdom Environmental Mutagen Society (UKEMS) and should stand as an important landmark in genetic toxicology.
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Content
Introduction; Bacterial Mutation (Core Study); Modification of the Bacterial Mutagenicity Assays; Yeast Genotoxicity Assays; Point Mutation Assays in Cultured Mammalian Cells; 'In Vitro' Cytogenetics; Unscheduled DNA Synthesis; Comparison of 59 Preparations; 'In Vivo' Cytogenetics; 'In Vivo' Assays and the Metabolism of the Test Compounds; General Discussion; Index.