Systems Biology
Properties of Reconstructed Networks
Published on 16. January 2006
Book
Hardback
336 pages
978-0-521-85903-5 (ISBN)
Description
Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook, devoted to systems biology, describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisites are some knowledge of linear algebra and biochemistry. Though the links between the mathematical ideas and biological processes are made clear, the book reflects the irreversible trend of increasing mathematical content in biology education. Therefore to assist both teacher and student, in an associated website Palsson provides problem sets, projects and Powerpoint slides, and keeps the presentation in the book concrete with illustrative material and experimental results.
Reviews / Votes
'... [deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology ... a welcome departure from the typical biology textbook ... a very readable introduction to the subject ... this is an exciting time for biology. The author exposes readers to enough material that the research literature in quantitative systems biology should become accessible.' Physics TodayMore details
Language
English
Place of publication
Cambridge
United Kingdom
Target group
College/higher education
Professional and scholarly
Dimensions
Height: 260 mm
Width: 183 mm
Thickness: 23 mm
Weight
828 gr
ISBN-13
978-0-521-85903-5 (9780521859035)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Book
01/2015
2nd Edition
Cambridge University Press
€127.20
Shipment within 15-20 days
Additional editions
E-Book
03/2006
1st Edition
Cambridge University Press
€73.99
Available for download
Person
Bernhard O. Palsson, Professor of Bioengineering and Adjunct Professor of Medicine, University of California, San Diego.
Content
Preface; 1. Introduction; 2. Basic concepts in systems biology; Part I. Reconstruction of Biochemical Networks: 3. Metabolic networks; 4. Regulatory networks; 5. Signalling networks; Part II. Mathematical Representation of Reconstructed Networks: 6. Basic features of S; 7. Topological properties; 8. Fundamental subspaces; 9. Null space of S; 10. The left null space of S; 11. The row and column spaces of S; Part III. Capabilities of Reconstructed Networks: 12. Dual causality; 13. Properties of solution spaces; 14. Sampling properties of solution spaces; 15. Finding functional states; 16. Parametric sensitivity; 17. Epilogue; Appendix A: nomenclature and abbreviations; Appendix B: E. coli core metabolic network; Bibliography; Index.