Recent Advances in the Analysis of Genetic Traits
A Celebration of the 30th Anniversary of the Haseman-Elston Method. Special Issue: 'Human Heredity 2003, Vol. 55, No. 2-3'. Special Topic Issue: Human Heredity 2003, Vol. 55, No. 2-3
Published on 5. September 2003
Book
Paperback/Softback
78 pages
978-3-8055-7619-2 (ISBN)
Description
This special issue of Human Heredity celebrates the 30th anniversary of the seminal method for quantitative linkage analysis developed by Joseph K. Haseman and Robert C. Elston. The editors invited nine peer-reviewed contributions from respected researchers in the field which present new methods and review relevant topics that in one way or another expand on the framework of the Haseman-Elston (HE) method. The new methods described include - adding further power to the HE method for detecting linkage through weighting sums and differences, - an X-linked extension of the revised HE algorithm, - efficiency robust tests for mapping quantitative traits using extremely discordant sib pairs, - regression-based sib-pair linkage analysis for binary traits, and - a method for evaluating the results of Bayesian model selection. Furthermore, regression models for linkage and the issues of traits, covariates, heterogeneity, and interaction are discussed as are information perspectives on the HE method. Bringing together new and outstanding research by leading scientists in the field, this publication will be of value to all those interested in statistical genetics, quantitative biology, and genetic epidemiology.
More details
Language
English
Place of publication
Basel
Switzerland
Target group
College/higher education
Professional and scholarly
Illustrations
11
35 s/w Tabellen, 11 s/w Abbildungen
11 fig., 35 tab.
Dimensions
Height: 28 cm
Width: 21 cm
Weight
260 gr
ISBN-13
978-3-8055-7619-2 (9783805576192)
Schweitzer Classification
Content
Part 1 Original Papers: Adding Further Power to the Haseman and Elston Method for Detecting Linkage in Larger Sibships - Weighting Sums and Differences, Shete, S., Jacobs, K.B., Elston, R.C.; Regression Models for Linkage - Issues of Traits, Covariates, Heterogeneity, and Interaction, Schaid, D.J., Olson, J.M., Gauderman, W.J., Elston, R.C.; X-Linked Extension of the Revised Haseman- Elston Algorithm for Linkage Analysis in Sib Pairs, Wiener, H., Elston, R.C., Tiwari, H.K.; Effect of Box-Cox Transformation on Power of Haseman-Elston and Maximum-Likelihood Variance Components Tests to Detect Quantitative Trait Loci, Etzel, C.J., Shete, S., Beasley, T.M., Fernandez, J.R., Allison, D.B., Amos, C.I. Part 2 Efficiency Robust Tests for Mapping Quantitative Trait Loci Using Extremely Discordant: Sib Pairs: Freidlin, B., Zheng, G., Li, Z., Gastwirth, J.L.; Regression-Based Sib Pair Linkage Analysis for Binary Traits, Zeegers, M.P.A., Rice, J.P., Rijsdijk, F.V., Abecasis, G.R., Sham, P.C.; Information Perspectives of the Haseman-Elston Method: Wright, F.A.; A Simple Nonparametric Test for Linkage with Sib-Pair Censored Event Time Observations, Wei, E., Wei, L.J., Xu, X.; A Method for Evaluating the Results of Bayesian Model Selection - Application to Linkage Analyses of Attributes Determined by Two or More Genes, Suh, Y.J., Ye, K.Q., Mendell, N.R.