The Orexin/Hypocretin System
Physiology and Pathophysiology
Published on 15. August 2005
Book
Hardback
416 pages
978-1-58829-444-9 (ISBN)
Description
The Orexin/Hypocretin System provides an overview of all the recent exciting discoveries in the field as well as new findings such as ligand replacement and gene therapies in the animal models of narcolepsy. Several contributions cover sleep and the multiple systems involved in its regulation.
More details
Series
Edition
2005 ed.
Language
English
Place of publication
Totowa
United States
Target group
Professional and scholarly
Professional/practitioner
Product notice
sewn/stitched
Cloth over boards
Illustrations
142 s/w Abbildungen, 9 farbige Abbildungen
416 p. 151 illus., 9 illus. in color.
Dimensions
Height: 260 mm
Width: 183 mm
Thickness: 30 mm
Weight
1062 gr
ISBN-13
978-1-58829-444-9 (9781588294449)
DOI
10.1385/1592599508
Schweitzer Classification
Other editions
Additional editions
Book
12/2010
Humana Press Inc.
€213.99
Shipment within 15-20 days
E-Book
11/2007
1st Edition
Humana
€213.99
Available for download
Content
History.- History and Overview of Orexin/Hypocretin Research.- Overview of the Orexin/Hypocretin Neuronal System.- Orexin and Orexin Receptors.- Orexin Projections and Localization of Orexin Receptors.- Neuronal Responses to Hypocretin/Orexin.- Afferent System of Orexin Neurons.- Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids.- Hypocretin Measurements in the CSF, and Blood and Brain Tissue.- Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTP?S Autoradiography.- Physiology.- Orexin System and Feeding Behavior.- Orexins and the Autonomic Nervous System.- Neuroendocrine Role of the Orexins (Hypocretins).- The Orexin/Hypocretin System and Stress and Emotion.- Physiology.- Hypocretin as a Wakefulness Regulatory Peptide.- Hypocretin/Orexin Tonus and Vigilance Control.- Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance.- Orexin and Hypothalamic Control of Sleep and Waking.- Hypocretin/Orexin and Motor Function.- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency.- Overview of Human Narcolepsy.- Canine Models of Narcolepsy.- Rodent Models of Human Narcolepsy-Cataplexy.- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency.- Hypocretin Deficiency in Human Narcolepsy.- Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy.- Hypocretin Measures in Psychiatric Disorders.- Neuroendocrinology of Human Narcolepsy.- Narcolepsy and Autoimmunity.- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency.- Pharmacology of Hypocretin/Orexin Peptides and Small Molecules.- Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides.- Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy.