Dermatologic Immunity
1st Edition
Published on 26. May 2008
Book
Hardback
382 pages
978-3-8055-8391-6 (ISBN)
Description
The skin, being the largest organ of the body, is constantly attacked by a diverse array of pathogenic agents including bacteria, viruses and fungi; it also suffers from solar damage and wide fluctuations in temperature and humidity. In some individuals, the immune system, which normally offers protection against fatal external assaults, can malfunction and cause chronic inflammation in the absence of a known pathogen, resulting in a host of disorders categorized as autoimmune skin diseases. This volume contains a series of 19 review articles on a wide range of autoimmune disease processes in the skin. Featuring disorders of humoral as well as cellular immunity, it covers allergic contact dermatitis, toxic epidermal necrolysis, psoriasis, atopic dermatitis, cutaneous lupus erythematosus, bullous pemphigoid, pemphigus foliaceus, lichen planus, vitiligo, scleroderma, alopecia areata and dermatomyositis. For these diseases, the latest insights into their etiology and pathophysiology as well as therapeutic strategies are presented by experts in the fields of dermatology, genetics, immunology and pathology. In addition, overviews of the skin as an active immune organ and of the immune privilege of the skin are included. Comprehensive and up-to-date, this book is recommended for basic and clinical researchers, allergists, immunologists, dermatologists, internists and anyone interested in autoimmunity.
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Content
Allergic Contact Dermatitis: Gober, M.D.; Gaspari, A.A.; Immune Privilege and the Skin: Ito, T.; Meyer, K.C.; Ito, N.; Paus, R.; Immunobiology of Acute Cytotoxic Drug Reactions: Nickoloff, B.J.; Psoriasis: Nestle, F.O.; Atopic Dermatitis in 2008: Chan, L.S.; Cutaneous Lupus Erythematosus: Molecular and Cellular Basis of Clinical Findings: Kuhn, A.; Sontheimer, R.D.; Bullous Pemphigoid and Related Subepidermal Autoimmune Blistering Diseases: Olasz, E.B.; Yancey, K.B.; Pemphigus Vulgaris and Its Active Disease Mouse Model: Amagai, M.; Pemphigus Foliaceus: Dasher, D.; Rubenstein, D.; Diaz, L.A.; Autoimmunity to Type VII Collagen: Epidermolysis Bullosa Acquisita: Remington, J.; Chen, M.; Burnett, J.; Woodley, D.T.; Pathomechanisms of Lichen Planus Autoimmunity Elicited by Cross-Reactive T Cells: Shiohara, T.; Mizukawa, Y.; Takahashi, R.; Kano, Y.; Autoimmune Etiology of Generalized Vitiligo: Le Poole, I.C.; Luiten, R.M.; The Genetics of Generalized Vitiligo: Spritz, R.A.; Scleroderma: Gilliam, A.C.; Alopecia Areata: King Jr., L.E.; McElwee, K.J.; Sundberg, J.P.; Dermatomyositis: Krathen, M.S.; Fiorentino, D.; Werth, V.P.; Novel Mechanism for Therapeutic Action of IVIg in Autoimmune Blistering Dermatoses: Michael, D.; Grando, S.A.; Skin Involvement in Systemic Autoimmune Diseases: Rashtak, S.; Pittelkow, M.R.; Therapeutics and Immune-Mediated Skin Disease: Gordon, K.B.; Satoskar, R.; Author Index; Subject Index.