Human Cancer Viruses
Principles of Transformation and Pathogenesis.
1st Edition
Published on 1. July 2008
Book
Hardback
244 pages
978-3-8055-8576-7 (ISBN)
Description
The first identification of a tumor-causing virus, Rous sarcoma virus, occurred almost 100 years ago, but it was not until the 1970s that the genetic basis for oncogenesis by this and other acutely transforming retroviruses was appreciated. Since then, numerous viral oncogenes and their corresponding cellular proto-oncogene counterparts have been identified, and these studies have contributed much to our understanding of crucially important aspects of cell biology and transformation. This book provides an up-to-date overview of the 6 major viruses that cause human cancers - HPV, HBV, HCV, EBV, KSHV and HTLV-1 - with respect to their molecular biology and epidemiology and to clinical aspects of disease, therapy and prevention. Contributed by over a dozen internationally renowned scientists, the chapters are comprehensively written and illustrated. The book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to understand the mechanisms leading to cellular transformation and oncogenesis by these viruses as a basis for the development of specific therapeutic and antiviral treatments.
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Content
Foreword: Chan, S.H.H.; Preface: Nicholas, J.; Jeang, K.-T; Wu, T.-C.; Molecular Epidemiology of Human Papillomavirus Infection: Gillison, M.L.; Molecular Pathogenesis of the Human Papillomavirus: Mao, C.-P.; Wu, T.-C.; Human Papillomavirus Vaccines: Roden, R.; Hung, C.-F.; Monie, A.; Wu, T.-C.; Hepatitis C Virus Genetics and the Discovery of Mechanism-Based Inhibitors of the NS3/4A Protease and NS5B Polymerase: LaFemina, R.L.; Role of the Hepatitis B Virus in Hepatocellular Carcinoma: Toh, S.-T.; Lee, C.G.; Carcinogenesis Induced by Hepatitis B Virus: Cougot, D.; Buendia, M.-A.; Neuveut, C.; Disease and Pathogenesis Associated with Epstein-Barr Virus: Ambinder, R.F.; The Biology and Molecular Biology Underlying Epstein-Barr Virus Oncogenesis: Martin, H.J.; Hayward, S.D.; Kaposi-Sarcoma-Associated Herpesvirus. Clinical Diseases and Viral Pathogenesis: Damania, B.; Dittmer, D.P.; Molecular Biology of Human Herpesvirus 8 Neoplasia: Chaudhary, P.M.; Nicholas, J.; Human Cancer Viruses. Human T Cell Leukemia Virus Type 1 and 2: Mechanisms of Pathogenesis: Arnold, J.; Green, P.L.; Chromosomal Instability and Human T Cell Leukemia Virus 1 Transformation: Chi, Y.-H.; Jeang, K.-T.; Author Index; Subject Index.