
Principles of Nucleic Acid Structure
Academic Press
2nd Edition
Published on 14. October 2021
Book
Paperback/Softback
454 pages
978-0-12-819677-9 (ISBN)
Description
Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA).
This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.
This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.
More details
Edition
2nd edition
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Product notice
Paperback (trade)
Unsewn / adhesive bound
Dimensions
Height: 234 mm
Width: 191 mm
Thickness: 23 mm
Weight
954 gr
ISBN-13
978-0-12-819677-9 (9780128196779)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions

Stephen Neidle | Mark Sanderson
Principles of Nucleic Acid Structure
E-Book
10/2021
2nd Edition
Academic Press
€99.95
Available for download
Previous edition

Stephen Neidle
Principles of Nucleic Acid Structure
Book
11/2007
Academic Press
€76.74
Article exhausted; check for reprint
Persons
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs. Mark Sanderson is a Visiting Professor of Biophysics in the Dept of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London. Recent structural studies in his laboratory have centred on type-II topoisomerase-DNA-drug complexes in collaboration with Prof. Mark Fisher's group at St. George's University of London using cryo-EM and X-ray crystallography, and the study of novel nucleic acid-protein complexes.
Author
Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UK
Visiting Professor, Faculty of Medicine, Imperial College London, UK
Content
1. Methods for Studying Nucleic Acid Structure
2. The Building-Blocks of DNA and RNA
3. DNA Structure as Observed in Fibers and Crystals
4. Non-standard and Higher-Order DNA Structures: DNA-DNA Recognition
5. Principles of Small Molecule-DNA Recognition
6. RNA Structures and Their Diversity
7. Principles of Protein-DNA Recognition
8. RNA Binding Proteins
2. The Building-Blocks of DNA and RNA
3. DNA Structure as Observed in Fibers and Crystals
4. Non-standard and Higher-Order DNA Structures: DNA-DNA Recognition
5. Principles of Small Molecule-DNA Recognition
6. RNA Structures and Their Diversity
7. Principles of Protein-DNA Recognition
8. RNA Binding Proteins