Regulation of Aldosterone Biosynthesis
Published on 23. January 2012
Book
Paperback/Softback
152 pages
978-3-642-96064-2 (ISBN)
Description
Most of our knowledge of the physiological control of aldosterone secretion is based on animal experiments and clinical studies which were carried out in the 1950s and early 1960s by a large number of inspired, ingenious and meticulous researchers. Their work has been excellently reviewed by-among others-MULLER (1963), BLAIR WEST et al. (1963), LARAGH and KELLY (1964), GANONG et al. (1966), MULROW (1966), DAVIS (1967) and GROSS (1967). According to the majority of these investigators, aldosterone secretion is primarily regulated by the renin-angiotensin system, with plasma sodium and potassium levels and pituitary secretion of ACTH playing important secondary roles. During the last six years, this hypothesis has been generally accepted and has only occasionally been challenged. The following is an attempt to take-from the perspective of a relatively simple in vitro model-a new look at the efferent axis of the apparently very complex control system maintaining adequate aldosterone production in the mammalian organism. My views are based mainly on a series of experiments which I have performed in order to study more closely the interactions of adrenocortical tissue with substances capable of directly influencing aldosterone bio synthesis.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1971
Language
English
Place of publication
Heidelberg
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Product notice
Paperback (trade)
Illustrations
black & white illustrations
Dimensions
Height: 23.5 cm
Width: 15.5 cm
Thickness: 8 mm
Weight
240 gr
ISBN-13
978-3-642-96064-2 (9783642960642)
DOI
10.1007/978-3-642-96062-8
Schweitzer Classification
Other editions
Additional editions
J. Rg M Ller | J'Urg M'Uller
Regulation of Aldosterone Biosynthesis
Book
01/1971
Springer
€91.07
Article exhausted; check for reprint
Content
I. Zona Glomerulosa of the Adrenal Cortex: Source of Aldosterone.- II. Pathway of Aldosterone Biosynthesis.- III. Aldosterone Biosynthesis by Cell-Free Systems.- IV. Factors Directly Influencing Aldosterone Biosynthesis in Short-Term Incubation or Perfusion Experiments.- 1. Angiotensin II.- 2. Monovalent Cations.- a) Sodium.- b) Potassium.- c) Ammonium, Rubidium, and Caesium.- 3. Bivalent Cations.- a) Calcium.- b) Magnesium.- 4. ACTH.- 5. Cyclic AMP.- 6. NADPH.- 7. Serotonin.- a) Related Compounds.- b) Serotonin Antagonists.- 8. Specific Inhibitors of Steroidogenic Enzymes.- a) Metopirone.- b) Su 8000, Su 9055, and Su 10 603.- c) Aminoglutethimide.- 9. Inhibitors of Protein Synthesis.- a) Actinomycin D.- b) Cycloheximide.- c) Puromycin.- 10. Steroid Hormones.- a) Corticosteroids.- b) Androgens and Estrogens.- 11. Ouabain.- V. Alterations in Aldosterone Biosynthesis and Secretion in Long-Term Experiments and Diseases.- 1. Alterations in Sodium Balance.- a) Morphological Changes.- b) Histochemical Changes.- c) Altered Sensitivity to Aldosterone-Stimulating Substances.- d) Sites of Action in the Biosynthetic Pathway.- e) Role of the Renin-Angiotensin System.- 2. Alterations in Potassium Balance.- 3. Exogenous Angiotensin and Renin.- a) Aldosterone Stimulation by Pressor and Non-Pressor Doses.- b) Selectivity of Aldosterone Stimulation.- c) Persistence of Aldosterone Stimulation.- d) Effect on Sodium Balance.- e) Renin Antibodies.- f) Morphological and Histochemical Alterations of the Adrenal Cortex.- 4. Renal Hypertension.- a) Renovascular and Malignant Hypertension in Man.- b) Experimental Renovascular Hypertension.- 5. Bilateral Nephrectomy.- 6. Hypophysectomy and Hypopituitarism.- 7. Lesions of the Central Nervous System.- a) Brain Lesions.- b) Pinealectomy.- 8. Mineralocorticosteroids.- 9. Glucocorticosteroids and ACTH.- 10. Estrogens and Progestogens.- a) Exogenous Estrogens.- b) Exogenous Progestogens.- c) Oral Contraceptive Medication.- d) Menstrual Cycle.- e) Pregnancy.- 11. Heparin and Heparinoids.- VI. Conclusions.- 1. Multiplicity of Aldosterone-Stimulating Substances.- 2. "Adrenoglomerulotropins".- 3. Uniform Mode of Action of Aldosterone-Stimulating Compounds.- a) Site of Action in the Biosynthetic Pathway.- b) Action on the Cell Membrane.- c) Dependence on Protein Synthesis.- 4. Regulation of the Final Steps of Aldosterone Biosynthesis.- 5. Zona Glomerulosa Width.- 6. Species Differences.- 7. Predominance of the Renin-Angiotensin System in the Physiological Control of Aldosterone Secretion?.- 8. Multifactorial Control of Aldosterone Biosynthesis.- References.- Acknowledgements.