Progress in Respiratory Research / Lung Surfactant: Basic Research in the Pathogenesis of Lung Disorders

Pulmonary surfactant, a complex mixture composed of lipids and proteins lining the alveoli, is essential for normal lung function. Knowledge about lung surfactant has increased tremendously during recent decades. Two early clinical observations, namely that premature infants suffering from respiratory distress syndrome lack this material and that acute pulmonary failure in adults may also involve dysfunction of the surfactant system, directed research toward describing the structure and function of surfactant components. The knowledge gained has stimulated efforts to develop natural or synthetic surfactant for therapy. This book presents the most recent results of studies of lung disorders involving the surfactant system. Authoritative and up-to-date, it is a valuable resource for both clinicians and scientists interested in understanding more about the pathogenesis of these disorders.