Local-spinal Therapy of Spasticity
1st Edition
Published on 15. April 1988
Book
Paperback/Softback
VIII, 270 pages
978-3-540-18295-5 (ISBN)
Description
Historical photograph of spinal anaesthesia In 1884 the American neurologist J. L. eases. His discovery, however, marks the Corning, by blocking the neural con onset of the era of regional anaesthesia. It took almost one hundred years until his duction to the hind extremities of a dog by injecting cocaine-solution into the lumbar original idea of "local medication of the vertebral interspace, was the first to per cord" was again reconsidered due to two form spinal (or epidural?) anaesthesia [1]. reasons: At that time, he was unaware of the local I. The discovery of different drug receptors anaesthetic properties of cocaine (dis in the spinal cord made it possible, by in covered in the same year by C. Koller, who trathecal injection (or epidural appli cation, if the drug penetrates the dura), applied cocaine to the eye of one of his pa tients [3]) and did not intend to introduce to alter nociceptive or motor transmis an anaesthetic procedure. Corning's pri sion within the spinal cord. mary aim was the application of drugs in 2. Implantable devices for long-term appli proximity of the central nervous system, i. e. cation of drugs to specific sites of the spinal cord, in order to treat or even heal body, including the spinal spaces, were developed during the 1970's.
More details
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
College/higher education
Professional and scholarly
Research
Illustrations
94 s/w Abbildungen
VIII, 270 p. 94 illus.
Dimensions
Height: 24.4 cm
Width: 17 cm
Weight
590 gr
ISBN-13
978-3-540-18295-5 (9783540182955)
DOI
10.1007/978-3-642-72954-6
Schweitzer Classification
Other editions
Additional editions
Hermann Müller | Jan Zierski | Richard D. Penn
Local-spinal Therapy of Spasticity
E-Book
12/2012
Springer
€96.29
Available for download
Content
Preface.- Preface.- A Short Historical Review of Spasticity and Its Therapy.- A Short Historical Review of Spasticity and Its Therapy.- Basic Experiences.- Spinal Pharmacology of Agents which Alter Pain Transmission and Muscle Tone.- The Neuropharmacology of Baclofen.- Animal Experiments on the Spinal Action of Midazolam.- Intrathecal Injection of Antispastic Drugs in Rats: Muscle Relaxant Action of Midazolam, Baclofen, 2-Aminophosphonoheptanoic Acid (AP7) and Tizanidine.- CSF Compatibility of Antispastic Agents.- Dural Permeability to Bupivacaine, Baclofen and Midazolam: In Vitro Determination with Human Dura Mater.- Clinical Studies.- Pharmacotherapy of Spasticity.- Pumps in Pharmacotherapy.- Implantation of Ports and Pumps. Technique for Intrathecal Administration of Drugs.- Control of Spasticity with Intrathecal Morphine Sulfate.- Clinical Experience with Spinal Morphine, Midazolam and Tizanidine in Spasticity.- Chronic Intrathecal Baclofen for Severe Rigidity and Spasms.- Intrathecal Baclofen in Spasticity.- Chronic Intrathecal Administration of Baclofen in Treatment of Severe Spasticity.- Pharmacokinetics of Intrathecal Baclofen.- Intrathecal Baclofen in tetanus.- The Value of Spinal Cord Stimulation (SCS) in Treatment of Disorders of the Motor System.- Physostigmine Reversal of Baclofen-induced Sedation.- Surgical Treatment of Spasticity- A Review.