Cell Adhesion Molecules and Matrix Proteins
Role in Health and Diseases
Published on 30. June 1998
Book
Hardback
XV, 249 pages
978-3-540-64714-0 (ISBN)
Description
Both scientific research and commercial interest in investigating the role of cell adhesion molecules in complex cell-cell and cell-matrix interactions are growing at a rapid pace. The recent identification and manipulation of an expanding number of cell adhesion molecules (CAMs) provide an excellent opportunity for therapeutic and diagnostic interventions in a wide variety of disease processes including acute and chronic inflammatory diseases, vascular remodeling, autoimmune and thrombotic disorders, neurodegenerative complications, bacterial adhesion, angiogenesis and restenosis.
More details
Content
Recent advances in cell adhesion molecules and extracellular matrix proteins: potential clinical implications.- Integrins and signal transduction.- Antiplatelet therapies: platelet GpIIb/IIIa antagonists.- Role of alpha-IIb-beta3 integrin in metastasis.- Integrin alpha-v in health and disease - role of alpha-v beta3 in metastasis, vascular remodeling and angiogenesis.- Integrin alpha-v beta3: a therapeutic target for vascular remodeling.- Targeting VLA-4 integrin function: potential therapeutic implications.- Role of the integrin alpha4 beta1 (VLA-4) in inflammatory disorders.- The role of adhesion molecules in the gastrointestinal tract.- Epithelial neoplasms exhibit constitutive alterations in the expression of a repertoire of integrins transiently induced in acute wound responses.- CD44, Hyaluronan and lung cancer.- The role of P-selectin in thrombosis and vascular injury.- Osteopontin and integrin interactions: potential roles in cell adhesion and migration.- Fibronectin matrix: cellular regulations.- Soluble adhesion molecule as a potential diagnostic marker of disease states.