Nanotoxicology
Progress toward Nanomedicine, Second Edition
2nd Edition
Published on 16. November 2016
Book
Paperback/Softback
514 pages
978-1-138-03399-3 (ISBN)
Description
Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.
Topics include
The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products-with a focus on potential health and safety implications
Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body
Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications
Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels
Toxicity of nanomaterials to specific organ systems, cell-based targeting to tumors, and other biomedical applications
The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies
A roadmap for future research
The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.
Topics include
The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products-with a focus on potential health and safety implications
Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body
Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications
Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels
Toxicity of nanomaterials to specific organ systems, cell-based targeting to tumors, and other biomedical applications
The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies
A roadmap for future research
The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.
More details
Edition
2nd edition
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
Professional and scholarly
Professional Reference
Illustrations
106 s/w Abbildungen, 23 s/w Tabellen
23 Tables, black and white; 106 Illustrations, black and white
Dimensions
Height: 234 mm
Width: 156 mm
Thickness: 28 mm
Weight
775 gr
ISBN-13
978-1-138-03399-3 (9781138033993)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
03/2014
2nd Edition
CRC Press
€72.49
Available for download
E-Book
03/2014
2nd Edition
CRC Press
€72.49
Available for download
Book
03/2014
2nd Edition
CRC Press
€267.85
Article not available for order
Persons
Nancy A. Monteiro-Riviere is a Regents Distinguished Research Scholar and University Distinguished Professor of toxicology and director of the new Nanotechnology Innovation Center of Kansas State.
C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine, Edinburgh, United Kingdom.
C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine, Edinburgh, United Kingdom.
Content
Impacts of Nanotechnology on Biomedicine. Introduction to Biomedical Nanotechnology. Impact of Bionanointeractions of Engineered Nanoparticles for Nanomedicine. Rational Approach for the Safe Design of Nanomaterials. Characterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing. Exposure. Workplace Inhalation Exposure to Engineered Nanomaterials: Detection, Measurement, and Assessment. Nanotechnology in Consumer Products: Addressing Potential Health and Safety Implications for Consumers. Modeling. Quantitative Nanostructure-Activity Relationships: From Unstructured Data to Predictive Models for Designing Nanomaterials with Controlled Properties. Pharmacokinetics and Biodistribution of Nanomaterials. Methodologies and Techniques. Advanced Methodologies and Techniques for Assessing Nanomaterial Toxicity: From Manufacturing to Nanomedicine Screening. Detection Methods for the In Vivo Biodistribution of Iron Oxide and Silica Nanoparticles: Effects of Size, Surface Chemistry, and Shape. Quantitative Single-Cell Approaches to Assessing Nanotoxicity in Nanomedicine Systems. Imaging Techniques for Nanoparticles in Skin. Hazards. Safety Implications of Nanomaterial Exposure to Skin. Interspecies Comparisons of Pulmonary Responses to Fine and/or Nanoscale Particulates: Relevance for Humans of Particle-Overload Responses in the Rat Model. Current In Vitro Models for Nanomaterial Testing in Pulmonary Systems. Nanoparticles and the Immune System. Carbon Nanotubes and Cardiovascular Disease. Single- and Multiwalled Carbon Nanotubes Toxicity and Potential Applications in Neuroregeneration. Current In Vitro Models for Nanomaterial Testing: The Reproductive System. Current In Vitro Models for Nanomaterial Testing: Genotoxicity Issues. Cell-Based Targeting of Anticancer Nanomaterials to Tumors. Silver Nanoparticles in Biomedical Applications. Cytotoxicity of Conjugated and Unconjugated Semiconductor and Metal Nanoparticles. Risk Assessment. Issues Related to Risk Assessment of Nanomaterials.Risk Assessment of Engineered Nanomaterials: State of the Art and Roadmap for Future Research. Index.