
Platelets
Alan D. Michelson(Editor)
Academic Press
3rd Edition
Published on 10. December 2012
Book
Hardback
1400 pages
978-0-12-387837-3 (ISBN)
Article exhausted; check for reprint
Description
Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.
Reviews / Votes
"Platelets fills an important niche on the bookshelf of any academic hematologist. The user-friendly online access to the figures contained in the textbook will be especially useful for teaching purposes...this encyclopedia of the platelet contains critical information for physicians, educators, students, and research scientists." --HematologyTimes.com, 2014"Comprehensive and definitive, this third-edition reference integrates platelet biology, pathophysiology, and clinical medicine. Sixty-four chapters address biology, function, disease, disorders of platelet number or function, antiplatelet therapy, and therapy to increase numbers and/or function." --Reference and Research Book News 2013
"I've been reading various chapters for the past few days and have been marveling at the sheer depth and breadth. No other textbook or other reference source is comparable...You must have this book if your practice or interest even superficially touches on platelets." --Doody.com, 2013
"Platelets is the definitive current source of state- of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine." --Doody.com
"One might well question the value of a doorstopper-sized textbook in this era of instant Internet access to all variety of even the most arcane information. A notable exception, however, is the third edition of Michelson's Platelets. The surprising complexity of these anucleate cells and their diverse and ever enlarging roles in physiology and disease has attracted a large cadre of interdisciplinary researchers focused on various aspects of these roles. Having at ready hand a readable, authoritative, comprehensive and beautifully illustrated and cross-referenced volume makes for easy access to important information required by these researchers - both established senior investigators and their students." --Thomas P Stossel, MD, American Cancer Society Professor of Medicine Harvard Medical School Director, Translational Medicine Unit and center for Medical Innovation Senior Physician, Hematology Division Brigham & Women's Hospital, Boston, MA, USA
Reviews of the SECOND EDITION"...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells." --Journal of the American Medical Association"This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research." --BRITISH JOURNAL OF HAEMATOLOGY
"This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too." --Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars)
More details
Edition
3rd edition
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields
Illustrations
Approx. 350 illustrations (100 in full color)
Dimensions
Height: 276 mm
Width: 216 mm
Weight
3756 gr
ISBN-13
978-0-12-387837-3 (9780123878373)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Person
Dr. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts, U.S.A. He is also the Director of the Center for Platelet Research Studies (www.platelets.org) and the Director of the Thrombosis and Anticoagulation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. After receiving his medical degree with honors from the University of Adelaide, Australia, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Boston Children's Hospital, Brigham and Women's Hospital, and Harvard Medical School. In 2019 he received the International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. Dr. Michelson has been an invited participant in numerous National Institutes of Health working groups, international workshops and consensus conferences. He is the co-organizer and co-chair of the biennial International Platelets Symposium. Dr. Michelson is a past Chairman of the Platelet Physiology Scientific Subcommittee of the ISTH. He has published more than 450 original research articles, original research abstracts, and invited reviews - nearly all on the topic of platelets. Dr. Michelson has been the principal investigator on more than 100 research grants. He has been an invited speaker at over 200 major medical conferences worldwide. Dr. Michelson is an inventor on two awarded and three provisional U.S. patents.
Editor
Professor of Pediatrics and Professor of Medicine, Harvard Medical School, Boston, MA, USA; Director, Center for Platelet Research Studies and Director, Thrombosis and Anticoagulation Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA
Content
ForewordA Brief History of Ideas About Platelets in Health and Disease
Part One: Platelet Biology1. The Evolution of Mammalian Platelets2. Megakaryocyte Development and Platelet Formation3. The regulation of platelet life span4. Platelet Genomics 5. Platelet MicroRNAs6. The Platelet Proteome 7. Platelet Structure8. The Platelet Cytoskeleton9. Platelet Receptors 10. The GPIb-IX-V Complex 11. GPVI and CLEC-212. Integrin AlphaIIb Beta3 13. Protease-activated Receptors 14. The Platelet P2 Receptors15. PECAM-116. Interactions Between Platelets, Leukocytes and the Endothelium17. Inhibition of Platelet Function by the Endothelium18. Platelet Secretion19. Signal Transduction During Platelet Plug Formation20. Platelet Thrombus Formation in Flowing Blood21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Microparticles23. The Role of Platelets in Fibrinolysis24. The Role of Platelets in Angiogenesis 25. Platelet Function in the Newborn
Part Two: Tests of Platelet Function26. Clinical Tests of Platelet Function27. Platelet Counting28. Platelet Aggregation29. Flow Cytometry30. Monitoring of Antiplatelet Therapy31. Real Time In Vivo Imaging of Platelets During Thrombus Formation
Part Three: The Role of Platelets in Disease32. Atherothrombosis and Coronary Artery Disease 33. Central Nervous System Ischemia 34. Peripheral Vascular Disease35. Diabetes Mellitus36. Inflammation 37. Antimicrobial Host Defense38. Tumor Growth and Metastasis
Part Four: Disorders of Platelet Number and Function39. The Clinical Approach to Disorders of Platelet Number and Function 40. Immune Thrombocytopenia (ITP)41. Drug-induced Thrombocytopenia42. Heparin-induced Thrombocytopenia 43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome44. Thrombocytopenia in Pregnancy45. Thrombocytopenia in the Newborn46. Alloimmune Thrombocytopenia47. Inherited Thrombocytopenias 48. Pseudothrombocytopenia 49. Thrombocytosis and Essential Thrombocythemia50. Congenital Disorders of Platelet Function 51. Acquired Disorders of Platelet Function52. Cardiopulmonary Bypass
Part Five: Antiplatelet Therapy53. Aspirin 54. ADP Receptor Antagonists 55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists56. Dipyridamole57. Cilostazol58. Novel Antiplatelet Therapies
Part Six: Therapy to Increase Platelet Numbers and/or Function59. Thrombopoietin Mimetics 60. Desmopressin61. Factor VIIa62. Platelet Transfusion Medicine63. Making Platelets Ex Vivo 64. Gene Therapy for Platelet Disorders
Part One: Platelet Biology1. The Evolution of Mammalian Platelets2. Megakaryocyte Development and Platelet Formation3. The regulation of platelet life span4. Platelet Genomics 5. Platelet MicroRNAs6. The Platelet Proteome 7. Platelet Structure8. The Platelet Cytoskeleton9. Platelet Receptors 10. The GPIb-IX-V Complex 11. GPVI and CLEC-212. Integrin AlphaIIb Beta3 13. Protease-activated Receptors 14. The Platelet P2 Receptors15. PECAM-116. Interactions Between Platelets, Leukocytes and the Endothelium17. Inhibition of Platelet Function by the Endothelium18. Platelet Secretion19. Signal Transduction During Platelet Plug Formation20. Platelet Thrombus Formation in Flowing Blood21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Microparticles23. The Role of Platelets in Fibrinolysis24. The Role of Platelets in Angiogenesis 25. Platelet Function in the Newborn
Part Two: Tests of Platelet Function26. Clinical Tests of Platelet Function27. Platelet Counting28. Platelet Aggregation29. Flow Cytometry30. Monitoring of Antiplatelet Therapy31. Real Time In Vivo Imaging of Platelets During Thrombus Formation
Part Three: The Role of Platelets in Disease32. Atherothrombosis and Coronary Artery Disease 33. Central Nervous System Ischemia 34. Peripheral Vascular Disease35. Diabetes Mellitus36. Inflammation 37. Antimicrobial Host Defense38. Tumor Growth and Metastasis
Part Four: Disorders of Platelet Number and Function39. The Clinical Approach to Disorders of Platelet Number and Function 40. Immune Thrombocytopenia (ITP)41. Drug-induced Thrombocytopenia42. Heparin-induced Thrombocytopenia 43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome44. Thrombocytopenia in Pregnancy45. Thrombocytopenia in the Newborn46. Alloimmune Thrombocytopenia47. Inherited Thrombocytopenias 48. Pseudothrombocytopenia 49. Thrombocytosis and Essential Thrombocythemia50. Congenital Disorders of Platelet Function 51. Acquired Disorders of Platelet Function52. Cardiopulmonary Bypass
Part Five: Antiplatelet Therapy53. Aspirin 54. ADP Receptor Antagonists 55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists56. Dipyridamole57. Cilostazol58. Novel Antiplatelet Therapies
Part Six: Therapy to Increase Platelet Numbers and/or Function59. Thrombopoietin Mimetics 60. Desmopressin61. Factor VIIa62. Platelet Transfusion Medicine63. Making Platelets Ex Vivo 64. Gene Therapy for Platelet Disorders


