Progress in Applied Microcirculation / Microcirculation in Chronic Venous Insufficiency
15th Bodensee Symposium on Microcirculation, Lindau, June 1998.
Published in 1999
Book
Hardback
X, 216 pages
978-3-8055-6821-0 (ISBN)
Description
TThis volume contains expert articles on the physiology and function of the microvascular and microlymphatic systems, the physiology of microvascular fluid filtration and reabsorption, interactions between blood cells and the microvascular endothelium, and molecular mechanisms of leukocyte activation. The therapeutic goals in chronic venous insufficiency include reduction of postischemic leukocyte-endothelial cell interaction, repair of microvascular barrier and improvement of microlymphatic drainage. In addition to measures to counteract inflammatory reactions elicited by local ischemia, surgical procedures such as transplantation of lymph vessels and subfascial division of perforating veins by an endoscopic approach are reviewed. Written by leading experts in the field, this book provides the first synopsis of the role of microcirculatory disturbances in chronic venous insufficiency. It will be of particular interest to phlebologists, angiologists, dermatologists, gerontologists, vascular, plastic and reconstructive surgeons, and general physicians.
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Content
Part 1: the functional microcirculatory unit; assessment of factors influencing microvascular exchange; dynamics of the microlymphatic system; fluid "balance" between microcirculation and interstitium in skin and other tissues - revision of the classical filtration-reabsorption scheme; summary of discussion. Part 2: platelet-endothelial cell interactions in the postischemic microvasculature; pathophysiological mechanisms involving leucocytes in chronic venous insufficiency; Daflon 500mg reduces postischemic leukocyte-endothelial cell interactions and microvascular barrier dysfunction; summary of discussion. Part 3: new synthetic diosmetin derivatives - effects on different experimental models of the microcirculation; involvement of the lymphatic microcirculation in the pathophysiology of chronic venous insufficiency; treatment of microcirculation disorders in venous leg ulcer; lymphatic transplants in lymphoedema; summary of discussion. Part 4: association of lymphoedema and chronic venous disease; immunohistochemistry and molecular biology of skin with chronic venous insufficiency and venous ulceration; role of microangiopathy in the development of venous leg ulcers; application of microcirculatory principles in the treatment of chronic venous insufficiency; summary of discussion.